生殖医学杂志2017，Vol.26Issue(9)：902-906,5.DOI:10.3969/j.issn.1004-3845.2017.09.010
月经周期中内源性大麻素与性激素和促性腺激素的相关性研究分析
Correlation among endocannabinoid, sex steroids hormone and gonadotrophin in plasma during menstrual cycle
摘要
Abstract
Objective:To study plasma anandamide (AEA) level changes and the correlation among AEA,sex hormone and gonadotropin during menstrual cycle in normal women,and further explore whether AEA involves in the regulation of menstrual cycle and human fertility.Methods:The infertile patients with childbearing age and normal ovulation and menstrual cycle who underwent IVF due to fallopian tube obstruction or male factors in the reproductive medicine center from May to October 2015 were recruited in this study.According to the investigation purpose,the patients were divided into cross-sectional study group (79 patients) and longitudinal study group (10 patients) to examine plasma AEA changes during the menstrual cycle and the correlation among AEA and FSH,LH,E2,and progesterone.Results:In the cross-sectional study,the plasma AEA levels in the early follicular phase,late follicular phase,ovulation and luteal phase were (9.71± 0.86),(10.61± 1.05),(12.24 ± 0.73) and (7.46 ± 0.71) ng/ml respectively.The AEA level in ovulation phase was significantly higher than that in the early follicular phase and luteal phase (P＜0.05).In the longitudinal study,the plasma AEA level in four phases of menstrual cycle was (8.76 ± 0.91),(11.61 ± 1.28),(13.85 ± 1.18) and (8.50 ± 1.08) ng/ml respectively.The AEA level in ovulation phase was also significantly higher than the early follicular phase and luteal phase (P＜0.05).There was no significant difference in the AEA level between the crosssectional study group and the longitudinal study group (P＞ 0.05).There were significant positive correlations between plasma AEA level and serum LH,FSH and E2 level (P ＜ 0.05),but not with progesterone level (P=0.067).Conclusions:The plasma levels of AEA in normal women are changed during menstrual cycle,and were significantly correlated with sex hormones and gonadotropins.However,the specific interaction mechanism between AEA and FSH,LH,E2,progesterone needs to be further studied.关键词
内源性大麻素系统/花生四烯酸乙胺醇/月经周期/性激素/促性腺激素Key words
Endocannabinoid/Anandamide/Menstrual cycle/Sex steroid hormones/Gonadotrophin引用本文复制引用
崔娜,王露凝,王丽丽,赵志明,王玮,郝桂敏..月经周期中内源性大麻素与性激素和促性腺激素的相关性研究分析[J].生殖医学杂志,2017,26(9):902-906,5.基金项目
河北省卫计委医学科学研究重点课题计划(指令项目)(20150236) （指令项目）
