特产研究2017，Vol.39Issue(2)：14-23,10.DOI:10.16720/j.cnki.tcyj.2017.02.004
莽吉柿胶囊的药效学研究
The Mangosteen Capsule Pharmacodynamics Research
摘要
Abstract
To investigate the effects of Mangosteen Capsule on the lipid liver fat content and hemorrheology in rabbits with hyperlipidemia.The rabbits were divided into 6 teams,including normal control group;hyperlipidemia model group;low-dose group,middle-dose group and high-dose group of Mangosteen Capsule (30mg/kg,60mg/kg,120mg/kg),and Xuezhikang Capsule-treated group.The rabbits in normal control were fed with normal fodder,other rabbits were given high cholesterol feed,for six weeks.The animals were weighed after administration once weekly;took the blood by ear vein every two weeks and tested the contentss of TC/HDL-C,TC and LDL-C in serum.After administration,took the blood of rabbits by heart and detected the whole blood viscosity,plasma viscosity and hematocrit;and the contentss of TC and TG in hepatic tissue.Compared with normal control,the contentss of LDL-C,TC and TC/HDL-C in serum of rabbits in model group increased,and there was significant difference;in comparison with model group,the low whole blood viscosity,high whole blood viscosity and plasma viscosity all decreased,in low-dose group,middle-dose group and high-dose group of Mangosteen Capsule;the high whole blood viscosity and hematocrit declined obviously;the contents ofTC,LDL-cho,TC/HDL-cho and TG in serum decreased as well;the contents of TC and TG in liver decreased,which led to the remarkable decrease of liver coeeficient.The contents of TC/HDL-C decreased significantly,which is better than Xuezhikang Capsule-treated group (P ＜ 0.05).The prophylactic administration of Mangosteen capsule can inhibit the formation of experimental hyperlipidaemia in rabbit significantly.,and improve the characteristics of hemorheology of experimental hyperlipidaemia rabbit.关键词
莽吉柿胶囊/高脂血症/血液流变学/药效学Key words
Mangosteen capsule/hyperlipidemia/blood rheology/blood fat liver fat分类
医药卫生引用本文复制引用
王振洲,李平亚,张楠淇,王翠竹,李生,祁增,朱海林,郑炳真,刘金平..莽吉柿胶囊的药效学研究[J].特产研究,2017,39(2):14-23,10.基金项目
吉林省基金项目(20150307002YY) （20150307002YY）
