天津中医药2017，Vol.34Issue(9)：587-590,4.DOI:10.11656/j.issn.1672-1519.2017.09.04
消岩汤调整黄芪剂量联合GP方案治疗非小细胞肺癌的临床观察
Clinical observation of Xiaoyan decoction adjusted dose of Astragalus combined with GP regimen in the treatment of non-small cell lung cancer
摘要
Abstract
[Objective] To observe Xiaoyan decoction adjusted dose of Astragalus combined with GP regimen in the treatment of non-small cell lung cancer. [Methods] Using completely randomized method, 90 patients in The First Affiliated Hospital of Tianjin University of traditional Chinese medicine of non-small cell lung cancer were randomly divided into treatment group (Xiaoyan decoction 60 g of Astragalus combined with GP ) and control group ( Xiaoyan decoction combined with GP ) . Different doses of Astragalus in Xiaoyan decoction of qi deficiency and stasis type of non-small cell lung cancer incidence of bone marrow suppression (level of WBC) and the influence of grading, cytokines, immune function, quality of life were observed. [Results] After 1 cycles of chemotherapy, the efficiency rate was 62.2％in the treatment group and 55.6％in the control group. There was no significant difference between two groups (P>0.05). In the aspect of suppression in bone marrow, WBC decreased level, recovery degree and incidence of bone marrow suppression in the treatment group was better than the control group (P<0.05). Treatment group was significantly better than the control group in bone marrow suppression grading. In immune function, level of CD3+, CD4+and CD4+/CD8+in treatment group were significantly increased than control group (P<0.05). In the cytokine after treatment, IL-6, GM-CSF of treatment group compared with the control group were increased significantly . There were statistically significant differences ( P<0 . 05 ) . In terms of quality of life , the change of KPS score between the two groups was statistically significant (P<0.05). [Conclusion] Increase the dosage of Astragalus in Xiaoyan decoction combined with chemotherapy in the treatment of non-small cell lung cancer can improve chemotherapy-induced bone marrow suppression, decreased immune function, cytokines reduce and the quality of life. Clinical efficiency is more obvious.关键词
黄芪/剂量/骨髓抑制/化疗/非小细胞肺癌Key words
Astragalus/dosage/bone marrow suppression/chemotherapy/non-small cell lung cancer分类
医药卫生引用本文复制引用
张丽丽,贺斌,王园园,贾英杰..消岩汤调整黄芪剂量联合GP方案治疗非小细胞肺癌的临床观察[J].天津中医药,2017,34(9):587-590,4.基金项目
国家自然科学基金项目(81273937). （81273937）
