天然产物研究与开发2017，Vol.29Issue(8)：1270-1276,1438,8.DOI:10.16333/j.1001-6880.2017.8.002
川黄柏果实中的化学成分及抗肿瘤活性
Chemical Constituents and Anti-tumor Activity from the Fruits of Phellodendronchinense Schneid
摘要
Abstract
Ten compounds were obtained from the ethanol extract of the fruits of Phellodendron chinense Schneid by applying various chromatographic techniques.Their structures were elucidated and identified as 23-aldehyde-tirucall-7-ene3-one (1),(23 R,24S)-21-oxomelianodiol (2),33,22S-dihydroxy-tirucalla-7,24-dien-23-one (3),21,23-lactone-24,25 dihydroxy-tirucall-7-ene-3-one (4),Aphagranins F (5),24,25-epoxy-tirucall-7-ene-3,23-dione (6),Friedelin (7),Rutaecarpine (8),(2E,4E,8Z)-N-isobutyl tetradecatrienamide (9),7-Demethylsuberosin (10) respectively,based on the spectral data.Among them,compoundl were new natural products,2-5,7 were obtained from the fruits of P.chinense for the first time.Compound 3 and 5can inhibit the proliferation of MDA and K562 cells,respectively,their IC50 were 7.38 (± 3.24) μmol/L,3.86 (± 2.71) μmol/L,accordingly.关键词
川黄柏/化学成分/果实/结构鉴定Key words
Phellodendronchinense Schneid/chemical constituents/fruits/structural elucidation分类
医药卫生引用本文复制引用
晏晨,张云东,王星慧,骆衡..川黄柏果实中的化学成分及抗肿瘤活性[J].天然产物研究与开发,2017,29(8):1270-1276,1438,8.基金项目
贵州省卫生计生委科学技术基金(gzwjkj2016-1-010) （gzwjkj2016-1-010）
贵州省2014年度“百千万”人才引进计划“千人创新创业人才”项目(2013-QR-008) （2013-QR-008）
安顺市科技创新平台建设项目(2016-7) （2016-7）
贵州省中医药管理局专项基金(QZYY-2015-093) （QZYY-2015-093）
