天然产物研究与开发2017，Vol.29Issue(8)：1284-1289,6.DOI:10.16333/j.1001-6880.2017.8.004
大鼠原代肝星状细胞活化过程中CCN家族表达研究
Expression of CCN Family during Rat Primary Hepatic Stellate Cells Activation
摘要
Abstract
Liver fibrosis is the pathological repair response of liver to injury and characteristic of activation and expanding of hepatic stellate cells (HSC) and excessive accumulation of extracelluar matrix proteins (ECM) in liver.CCN factors are the signaling matricellular protein,involving in tissue repair and fibrogenesis.In this study,the highly pure primary rat HSC was isolated and cultured for their transition into the myofibroblastic phenotype.These cultured HSCs were daily collected and characterized for the MF phenotypic features,and then mRNA expression of all CCNs genes within these transiting HSCs were analyzed with the real time QRT-PCR for a full assessment of the roles of CCNs during HSC trans-differentiation.关键词
CCN家族/肝星状细胞HSC/肝纤维化Key words
CCN family/hepatic stellate cell/hepatic fibrosis分类
生物科学引用本文复制引用
张艳军,董育红,李遂焰,陈渝萍..大鼠原代肝星状细胞活化过程中CCN家族表达研究[J].天然产物研究与开发,2017,29(8):1284-1289,6.基金项目
国家自然科学基金(81371675) （81371675）
