天然产物研究与开发2017，Vol.29Issue(8)：1302-1306,5.DOI:10.16333/j.1001-6880.2017.8.007
锁阳乙酸乙酯提取物改善慢性应激小鼠认知功能障碍的神经保护机制
Effect of Cynomoriumsongaricum Ethyl Acetate Extract on Cognitive Dysfunction Induced by Chronic Stress
摘要
Abstract
The mice given chronic unpredictable stress after ovariectomized was used to observe the effect of Cynomoriumsongaricumethyl acetate extract(ECS) on cognitive dysfunction induced by chronic stress.The Morris water maze was applied to test the spatial learning and memory ability.Western blot assay was used to test the expression of Syn and PSD95 in the hippocampus.HE staining was used to observe morphological change of hippocampal neurons.The results showed that the explore time of targeted quadrant of mice from ECS group increased (P ＜ 0.01) in the Morris water maze test.In addition,ECS can improve the expression of Syn(P ＜ 0.05) and PSD-95 (P ＜ 0.05) in Western blot assay.Compared with model group,the neurological form of pyramidal cells in hippocampus were improved by HE staining.Hippocampus nerve cell injury was improved.In conclusion,ECS can improve the expression of Syn and PSD-95,protect hippocampus nerve cell and improve the cognitive dysfunction.关键词
锁阳乙酸乙酯提取物/认知功能/慢性应激/神经保护/Syn/PSD-95Key words
Cynomoriumsongaricumethyl acetate extract/cognitive function/chronic stress/neuroprotection/Syn/PSD-95分类
医药卫生引用本文复制引用
马素亚,郑俊超,畅洪昇,田方泽,程丹,王旭,鲁艺..锁阳乙酸乙酯提取物改善慢性应激小鼠认知功能障碍的神经保护机制[J].天然产物研究与开发,2017,29(8):1302-1306,5.基金项目
教育部新世纪优秀人才项目(NCET-13-0695) （NCET-13-0695）
国家自然科学青年基金(81102623) （81102623）
