天然产物研究与开发2017，Vol.29Issue(8)：1307-1311,5.DOI:10.16333/j.1001-6880.2017.8.008
紫苏干预COPD系统性炎症的大鼠模型研究
Interventional Effect of Perilla frutescens (L.) Britt on Systemic Inflammation of COPD Rats
摘要
Abstract
Fifty-four SD rats were randomly divided into 3 groups:control (CK),general tobacco (GT) and new-type tobacco (NT).The COPD model was duplicated in cigarette smoke-exposed rats in order to reveal the biological effect of tobacco introduced Perilla frutescents (L.) Britt genes.ELISA analysis showed cigarette smoke can induce inflammatory response of COPD rats after 56 d exposure.Compared to GT group,the serum levels of CRP,IL-8 and TNF-α in NT group significantly decreased (P ＜ 0.05).The expression of NF-κB p65 in liver and spleen tissues was detected by immunohistochemical method.Compared to CK group,there was a significant increase in their levels in COPD rats.With the extension of exposure time,there were obvious differences between NT and GT group (P ＜ 0.05).The results indicated that the new-type tobacco can suppress the systemic inflammatory of smoking-related COPD and intervene in the overactivation of NF-κB in extrapulmonary tissues,resulting in delaying the progression of the disease.关键词
慢性阻塞性肺疾病/紫苏/香烟烟雾/系统性炎症Key words
chronic obstructive pulmonary disease/Perilla frutescents (L.) Britt/cigarette smoke/systemic inflammation分类
医药卫生引用本文复制引用
魏克强,李娟娟..紫苏干预COPD系统性炎症的大鼠模型研究[J].天然产物研究与开发,2017,29(8):1307-1311,5.基金项目
山西省回国留学人员科研资助项目(2013-024) （2013-024）
山西省重点研发计划(社会发展)(201603D321002) （社会发展）
