天然产物研究与开发2017，Vol.29Issue(8)：1312-1318,7.DOI:10.16333/j.1001-6880.2017.8.009
三花枪刀药中萜类和甾体成分研究
Terpenoids and Steroids from Hypoestes triflora
摘要
Abstract
In this study,15 compounds were isolated and purified from the 95％ EtOH extract from Hypoestes triflora by column chromatography on silica gel,Sephadex LH-20 and HPLC.Their structures were elucidated as 6-hydroxy-9,13-cyclomegastigma-4,9 (13)-dien-3-one (1),3β-hydroxy-β-ionone (2),3 α-hydroxy-megastigrna-4,7E-dien-9-one (3),5α,6α-epoxy-3α-hydroxy-megastigma-7E-en-9-one (4),loliolide (5),pisiferadinol (6),24-methylenecycloartanol (7),α-amyrin (8),3β-hydroxyurs-11-en-28,13β-olide (9),lupeol (10),achilleol A (11),6β-methoxyergosta-7,22E-dien-3β,5 α-diol (12),6β-ethoxyergosta-7,22E-dien-3β,5 α-diol (13),stigmast-4-en-3,6-dione (14),stigmast-4,22E-dien-3,6-dione (15),by modem spectroscopic methods.Compound 1 was isolated from nature resources for the first time,and compounds 2-15 were obtained from H.triflora for the first time.Compounds 6,12,15 showed significant cytotoxic activities against MDA-MB-468,AGS,HCT116,Hela,and MDA-MB-231 cells.关键词
三花枪刀药/化学成分/萜类/甾体/细胞毒活性Key words
Hypoestes triflora/chemical constituent/terpenoid/steroid/cytotoxic activity分类
医药卫生引用本文复制引用
邓振涛,冯维扬,丁林芬,苏佳,宋流东,吴兴德..三花枪刀药中萜类和甾体成分研究[J].天然产物研究与开发,2017,29(8):1312-1318,7.基金项目
国家自然科学基金(21402212) （21402212）
云南省应用基础研究计划(2015FB173) （2015FB173）
