天然产物研究与开发2017，Vol.29Issue(8)：1319-1323,5.DOI:10.16333/j.1001-6880.2017.8.010
红花石蒜生物碱成分研究
Alkaloids from the Bulbs of Lycoris radiata var.radiata
摘要
Abstract
On the basis of prophase studies in our laboratory,it was found that Lycorisradiata alkaloids had strong resistance activity against tobacco mosaic virus (TMV).In order to further study the mechanism of action,studyon the chemical compositions of L.radiate was carried out in this study.As a result,eleven compounds were isolated from L.radiate.Their structures were identified by 1H NMR,13C NMR,2D NMR and HR-ESI-MS as pancratinine D (1),hippeastrine (2),O-demethylhomolycorine (3),6o-O-methyllycorenine (4),lycoramine (5),tazettine (6),lycorine (7),lycoramine N-Oxide (8),O-demethylgalantamine (9),dihydrolycorine (10) and crinine (11).In addition,the anti-TMV activity of 1,3 and 10 were evaluated in vitro by inoculating half leaf method.All of them showed anti-TMV activity.The inhibition rate of 3 exceed positive control ningnanmycin.关键词
烟草花叶病毒/红花石蒜/生物碱/抗烟草花叶病毒活性Key words
tobacco mosaic virus/Lycoris radiata/alkaloids/anti-TMV activity分类
农业科技引用本文复制引用
靳朋举,张于,郝小江,王清,李顺林..红花石蒜生物碱成分研究[J].天然产物研究与开发,2017,29(8):1319-1323,5.基金项目
国家自然科学基金面上项目(31270404 （）
31470427) （）
