武警医学2017，Vol.28Issue(5)：475-477,3.
脂微球前列地尔联合依达拉奉治疗急性脑梗死疗效探讨
Influence of lipid microsphere alprostadil combined with edaravone onneurological function and serum S100B level of acute ischemic stroke patients
安占军 1徐立霞 2曹洁玮1
作者信息
- 1. 050081 石家庄,武警河北总队医院内二科
- 2. 050031石家庄,河北医科大学第四医院肿瘤内科
- 折叠
摘要
Abstract
Objective To investigate the influence of lipid microsphere alprostadil combined with edaravone on the neurological function and serum S100B level of patients with acute cerebral infarction.Methods Between June 2014 and June 2016,sixty patients with acute cerebral infatrction were enrolled and randomlv and equally divided into the combined grotup (lipid microsphere alprostadil and edaravone) and the control group (edaravone alone).All the patients received brain MRI examinations(DWI) before treatment,and NIHSS and serum S100B tests before treatment as well as at day 3,7 and 14 during treatment.The changes of NIHSS and serum S100B levels were compared between the two groups at different time points.Results NIHSS and serum S100B levels of the combined group at day 3,7 and 14 during treatment were significantly lower than those of the control group(P ＜ 0.0 1).There were two cases of disease progression in the control group,but with no cases of adverse reactions.In the combined group,there was one case of progression,two cases of headache,and one patient who appeared red-faced and felt slightly swollen.Conclusions Lipid microsphere alprostadil combined with edaravone can improve clinical efficacy and alleviate brain damage in patients with acute ischemic stroke.关键词
急性脑梗死/脂微球前列地尔/依达拉奉/NIHSS评分/血清S100B蛋白Key words
acute cerebral infarction/lipid microsphere alprostadil/edaravone/NIHSS/serum S100B分类
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安占军,徐立霞,曹洁玮..脂微球前列地尔联合依达拉奉治疗急性脑梗死疗效探讨[J].武警医学,2017,28(5):475-477,3.
