摘要
Abstract
Objective To study the clinical features as well as therapeutic outcomes of elderly patients with mantle cell lymphoma (MCL),identify the major prognostic factors and to explore the optimal approach.Methods We retrospectively analyzed 45 patients diagnosed with MCL in two hospitals between 2000 and 2007.Clinical data,including age,stage,performance status,international prognostic index,treatment modalities and clinical outcomes,were evaluated.Results The median age of the patients was 73 years (aged 60 to 84).The ratio of males to females was 3.3∶ 1.All the patients received combined chemotherapy.With a median follow-up of 38 months,the rates of 5-year overall and 2-year disease-free survivals were 17.3％ and 27.2％,respectively.None remained disease-free at year 3.Median progression free survival was 20 months.There was no significant difference between the patients who had received CHOP regimen or R-CHOP regimen.Univariate analysis showed that PS,serum LDH levels,existence of B symptoms,bone marrow and peripheral blood involvement were the prognostic factors of overall survival for MCL patients.Cox regression multivariable analysis showed that only PS and bone marrow involvement were of statistic significance for prognosis.Conclusions Elderly patients with MCL are usually characterized by late staging,poor curative effect,and short survival.PS and bone marrow involvement are independent risk factors which affect the prognosis of elderly patients with MCL.MCL cannot be cured by standard CHOP or R-CHOP regimen.Newly diagnosed patients should be treated with novel modalities in order to improve the outcomes.关键词
老年患者/套细胞淋巴瘤/临床特点/治疗/预后Key words
elderly patients/mantle cell lymphoma/clinical features/treatment/prognosis分类
医药卫生
