武警医学2017，Vol.28Issue(6)：573-577,5.
18F-FDOPA与18F-FDG PET/CT诊断脑肿瘤的系统评价
A systematic comparison of 18F-FDOPA PET/CT with 18F-FDG PET/CT for diagnosis of brain tumors
摘要
Abstract
Objective To compare the diagnostic value of 18 F-FDOPA and 18 F-FDG PET/CT scan in patients with brain tumors by Meta analysis.Methods Data on diagnostic experiments related to the diagnostic value of ~ F-FDOPA and 18 F-FDG PET/CT scan for brain tumors was retrieved from CNKI,CSJD,WanFang Database,CBM,PubMed,Embase,Cochrane Library by October 2016.The diagnostic value of 18 F-FDOPA and 18F-FDG PET/CT scan for brain tumors was compared.Meta-DiSc 1.4 software was used to analyze the pooled sensitivity (SEN),specificity (SPE),positive likelihood ratio (+ LR),negative likelihood ratio (-LR),diagnostic odds ratio (DOR) under curve (AUC) the two different imaging agents.Results A total of four studies met the inclusion criteria.According to the results of 18F-FDOPA in diagnosis of brain tumors,the pooled SEN was 0.97(95％ CI =0.90-1.00),SPE 0.67(95％ CI =0.45-0.84),2.31(95％CI=1.40-3.81),0.07(95％CI=0.02-0.24),DOR 39.72(95％CI =8.94-176.48),SROC AUC 0.9725,and Q * value.According to the diagnostic results of 18F-FD,the pooled SEN was 0.51 (95％ CI =0.39-0.63),0.75 (95％ CI =0.53-0.90),2.31 (95％ CI =0.70-3.61),0.07(95％ CI =0.47-0.86),DOR 2.55(95％ CI =0.82-7.92),SROC AUC 0.5848,and Q* value was 0.5638.Conclusions 18F-FDOPA PET/CT imaging is more sensitive than 18F-FDG in the diagnosis of brain tumors.18F-FDO-PA is of high diagnostic value for brain tumors and can be used as a reliable diagnostic method of brain tumors.关键词
脑肿瘤/PET/CT/18F-FDOPA/18F-FDGKey words
brain tumor/PET/CT/18F-FDOPA/18F-FDG分类
特种医学引用本文复制引用
黄世明,罗燕薇,李彦峰,杨洋,岳建兰,林志春..18F-FDOPA与18F-FDG PET/CT诊断脑肿瘤的系统评价[J].武警医学,2017,28(6):573-577,5.基金项目
天津市自然科学基金(13JCYBJC22000) （13JCYBJC22000）
武警后勤学院附属医院种子基金(FYQ201601) （FYQ201601）
