西安交通大学学报（医学版）2017，Vol.38Issue(5)：625-632,8.DOI:10.7652/jdyxb201705001
重视与遗传相关的卵巢癌
Attention should be paid to hereditary ovarian cancer
杨筱凤 1郭艳平1
作者信息
- 1. 西安交通大学第一附属医院妇产科,陕西西安 710061
- 折叠
摘要
Abstract
The occurrence of 20 to 25 percent of ovarian cancer is associated with genetic factors.Hereditary ovarian cancer includes genetic ovarian cancer and familial ovarian cancer.The genetic characteristics of tumors and the development of gene testing technology make it possible to detect tumor-related mutational genes by testing the gene of the proband and thus identify the other family members at risk and intervene early so as to realize early prevention and detection of the cancer.The paper reviews the genetic basis and pathogenesis of hereditary ovarian cancer as well as methods of detecting mutational genes, management of the proband, problems at present, and disease prevention for high-risk individuals.It stresses that we should pay attention to hereditary ovarian cancer in clinical work, identify the proband, and make comprehensive evaluation of risks of the patients` relatives so as to provide individualized guidance and carry out the concept of precision medicine.关键词
遗传性/家族性/卵巢癌/突变基因/基因检测/精准化治疗Key words
hereditary/familial/ovarian cancer/mutational gene/gene testing/precision treatment分类
医药卫生引用本文复制引用
杨筱凤,郭艳平..重视与遗传相关的卵巢癌[J].西安交通大学学报（医学版）,2017,38(5):625-632,8.
