西安交通大学学报（医学版）2017，Vol.38Issue(5)：661-664,4.DOI:10.7652/jdyxb201705007
Ghrelin对糖尿病大鼠心肌动作电位和瞬时外向钾电流的影响
Effects of ghrelin on action potential and transient outward potasiumcurrent in streptozotocin-induced diabetic cardiomyopathy rats
摘要
Abstract
Objective To study the effects of ghrelin on action potential (AP) and transient outside K+ current (Ito) in ventricular myocytes of diabetic cardiomyopathy (DCM) rats.Methods A rat model of DCM was established by single intraperitoneal injection of streptozotocin (STZ, 60mg/kg), and whole cell patch-clamp technique was used to record the effects of 10-7mmol/L ghrelin on AP and Ito current density in the DCM rat ventricular myocytes.Results Compared to DCM group, Ghrelin of 10-7mmol/L could significantly prolong APD50 [(12.49±2.32)％;n=7, P=0.037] and APD90 [(26.29±5.13)％;n=7, P=0.006] and decrease Ito current peak value [(23.14±3.07)％;n=9, P=0.021] in DCM rat ventricular myocytes.Conclusion Exogenous ghrelin is involved in the electrophysiological reconstruction of the heart of diabetic rats by decreasing Ito current and prolonging APD in STZ-induced DCM rat ventricular myocytes.关键词
ghrelin/糖尿病心肌病/动作电位/瞬时外向钾电流Key words
ghrelin/diabetic cardiomyopathy/action potential/transient outside potassium current分类
医药卫生引用本文复制引用
冯丹阳,孙强,陈莉娜,赵正杭,周筠..Ghrelin对糖尿病大鼠心肌动作电位和瞬时外向钾电流的影响[J].西安交通大学学报（医学版）,2017,38(5):661-664,4.基金项目
国家自然科学基金面上项目(No.81170176) （No.81170176）
陕西省科技统筹创新工程计划项目(No.2014KTCL03-10)Supported by the National Natural Science Foundation of hina(No.81170176)and Scientific and Technological Innovation Project of Shaanxi Province (No.2014KTCL03-10) （No.2014KTCL03-10）
