西北国防医学杂志2017，Vol.38Issue(8)：491-493,3.DOI:10.16021/j.cnki.1007-8622.2017.08.001
大株红景天对大鼠心肌缺血再灌注损伤的保护作用及机制
Protective effects of rhodilla rosea on myocardial ischemia reperfusion injury in rats
摘要
Abstract
Objective:To evaluate the protective effects and the mechanism of rhodilla rosea on myocardial ischemia reperfusion injury (MIRI) in rats.Methods:Fourty male SD rats were randomly divided into normal group,control group,MIRI model group,rhodilla rosea pretreatment group.Left anterior descending coronary artery of rats in latter two groups was ligated by ischemia 30 min then reperfusion 120 min and the rat MIRI model was constructed.MIRI model group was given sodium chloride and rhodilla rosea group was given rhodilla rosea for intravenous administration.The serum levels of inflammatory factors,the rat myocardial infarction area and caspase-3 protein expression were measured,and the myocardial damage degree was evaluated.Results:The myocardial infarction area,levels of inflammatory,caspase-3 protein expression in rhodilla rosea pretreatment group were significantly lower than those in MIRI model group.Conclusion:Rhodilla rosea can obviously lighten MIRI rat myocardial damage,its mechanism may be related to inhibiting inflammatory cytokines release and reduce caspase-3 protein expression.关键词
心肌缺血再灌注损伤/大株红景天/保护作用Key words
myocardial ischemia reperfusion injury/rhodilla rosea/protective effect分类
医药卫生引用本文复制引用
谢亮,刘晶,李建华,王静,马晓华,潘涛,宫剑滨..大株红景天对大鼠心肌缺血再灌注损伤的保护作用及机制[J].西北国防医学杂志,2017,38(8):491-493,3.基金项目
国家自然科学基金资助项目(81400238) （81400238）
