中国组织工程研究2017，Vol.21Issue(22)：3445-3451,7.DOI:10.3969/j.issn.2095-4344.2017.22.001
椎间置入充满碎骨的聚乳酸-聚羟基乙酸腰椎间融合器与自体骨:影响脊柱节段稳定性吗?
Polylactic acid-polyglycolic acid lumbar interbody fusion cage full of broken bones versus autologous bone: an influence on the spinal stability?
宋宏阁 1王佳爽 1李学涛 2郝光辉 1张勤安 1韩冰 1陈莉 1海玉杰 1刘华丰 1陈彦超1
作者信息
- 1. 郑州市第六人民医院骨科,河南省郑州市 450000
- 2. 郑州市第十六人民医院骨科,河南省郑州市 450000
- 折叠
摘要
Abstract
BACKGROUND:Along with the widespread application of biodegradable materials in the field of medicine and the in-depth research of biomechanics,the drawbacks of traditional medical metal materials are increasingly appearing.In recent years,researchers at home and abroad focus on biodegradable materials that are represented by high molecular polymer to seek new breakthroughs in the field of spinal instability.OBJECTIVE:To investigate biomechanical changes of polylactic acid-polyglycolic acid (PLGA) lumbar interbody fusion cage in the body and discusses its feasibility for treating segmental instability of the spine.METHODS:Forty-two healthy pigs (9 months old) were randomly divided into two groups (n=21),and L4/5 intervertebral disc nucleus pulposus was removed in all animals.In experimental group,PLGA lumbar interbody fusion cage filled with broken bone was implanted;and in control group,autologous bone was implanted.X-ray was performed to observe the fusion of operation segments at 4,12 and 72 weeks postoperatively.Feasibility of fibrous fusion was measured by biomechanical test.Histologically,bone graft fusion at the surgical site and material degradation were detected.RESULTS AND CONCLUSION:(1) Imaging examination:Bone graft fusion in two groups was not visible at 4 weeks after operation.Evidence of increasing fusion was found in the experimental group at 12 weeks after operation;a visible part of the bone bridge was found in the control group,in which there was one case of fusion.Degradation of the fusion cage with one case of fusion in experimental group was found after 72 weeks after operation,and two cases of fusion in the control group.(2) Biomechanical test:There was no difference in the spinal range of motion between the two groups in different states at 4 weeks after operation (P ＞ 0.05).The spinal range values of motion at most of the states at 72 weeks after operation were significantly lower than those at 4 weeks after operation.(3) Cell histology observation:With the passage of time,the materials in the experimental group degraded gradually;new bone grew slowly and then fast,with bone fusion step by step.Fusion results were similar in the two groups.Our experimental findings indicate that the PLGA lumbar fusion cage has good biocompatibility.In addition to the individual state (left flexion),the mechanical properties of the fusion cage are similar to that of autogenous bone,and the fusion cage enables the segmental reconstruction of the pig spine to the maximum extent.关键词
生物材料/骨生物材料/聚乳酸聚酯/腰椎间融合器/脊柱节段失稳分类
医药卫生引用本文复制引用
宋宏阁,王佳爽,李学涛,郝光辉,张勤安,韩冰,陈莉,海玉杰,刘华丰,陈彦超..椎间置入充满碎骨的聚乳酸-聚羟基乙酸腰椎间融合器与自体骨:影响脊柱节段稳定性吗?[J].中国组织工程研究,2017,21(22):3445-3451,7.
