心脑血管病防治2017，Vol.17Issue(4)：256-259,4.DOI:10.3969/j.issn.1009-816x.2017.04.04
慢性心力衰竭患者血浆TIMP-4、sES及FFA动态变化及预后判断
Study on Dynamic Variation of Plasma Levels of TIMP-4, sES and FFA in Patients with Chronic Heart Failure and the Prognosis Judgment
摘要
Abstract
Objective To explore the clinical value of the dynamic variation of plasma levels of the tissue inhibitor of metalloproteinase (TIMP)-4,soluble E selectin (sES) and free fatty acids (FFA) in patients with chronic heart failure (CHF) as well as the correlation of plasma levels of TIMP-4,sES and FFA to prognostic judgment.Methods A total of 118 patients with CHF were collected and divided into two groups according to the degree of CHF,which were mild group (73 cases,cardiac NYH class 2) and severe group (45 cases,cardiac NYHA class 3 to 4).The plasma levels of NT-proBNP,TIMP-4,sES and FFA were detected and compared between two groups at 1st,3th,6th,12th month post-therapy respectively.The survival rates were compared between two groups after one-year follow-up.The correlation between the above indexes and the risk factors of CHF survival rate were confirmed by multivariate Logistic analysis.Results At any point of time,plasma levels of the NT-proBNP,sES and FFA in severe group were significantly increased (all P ＜ 0.05) but the plasma level of TIMP-4 in severe group was significantly decreased (P ＜ 0.05) when compared with the mild group.As the duration of treatment prolonged,the plasma levels of NT-proBNP,sES and FFA in two groups were decreasing with statistical significance (all P ＜ 0.05) whereas theTIMP-4 in two groups were increasing with statistical significance (P ＜ 0.05).After a follow-up of one year,the survival rates in severe group were significantly lower than mild group (P =0.035)Compared to survival group,the plasma level of TIMP-4 in death group was significantly lower (P ＜ 0.05) whereas the NT-proB-NP,sES and FFA plasma levels of death group were significantly higher (all P ＜ 0.05).According to muhivariate Logistic analysis,the NT-proBNP,sES and FFA plasma levels were risk factors to the survival rate of CHF ((OR =0.02 ～ 2.20,P ＜ 0.05) while the TIMP-4 plasma level was protective factor to CHF (OR =0.50,P ＜ 0.05).Conclusions Since the plasma levels of TIMP-4,sES and FFA could assess the degree of CHF,they have predictive value for prognostic outcomes.关键词
慢性心力衰竭/组织型金属蛋白酶抑制剂-4/可溶性E选择素/游离脂肪酸Key words
Chronic heart failure, Metalloproteinase (TIMP)-4, Soluble E selectin (sES)/Free fatty acids/Prognosis分类
医药卫生引用本文复制引用
魏红随,王刚,刘兴芝..慢性心力衰竭患者血浆TIMP-4、sES及FFA动态变化及预后判断[J].心脑血管病防治,2017,17(4):256-259,4.基金项目
2015年度河北省医学科学研究重点课题计划(20150552) （20150552）
