心脑血管病防治2017，Vol.17Issue(4)：269-272,4.DOI:10.3969/j.issn.1009-816x.2017.04.08
阿托伐他汀钙预治疗在急性冠状动脉综合征患者PCI术中的应用价值
Value of Atorvastatin Calcium Pre-treatment in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
摘要
Abstract
Objective To explore the value of atorvastatin calcium pre-treatment in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).Methods 80 patients with acute coronary syndrome were randomly and equally allocated into treated group (n =40) and control group (n =40).The treated group was given atorvastatin calcium for 3 month before PCI while the other group was treated by PCI for the first time and without statins pre-treatment.The inflanmatory reaction and changes of myocardial injury markers were monitored at different time points (before PCI and 12 h and 24 h after PCI).TIMI flow grading of target vessel antegrade flow at 20 min after PCI was observed.The incidence of major adverse cardiovascular events (MACE) was followed up after PCI for 1 month.Results Compared with the control group,the levels of serum total cholesterol and triglyceride were significantly lower in treated group than those in control group (all P ＜ 0.05).The levels of cTnT,CK-MB,IL-6 and hs-CRP were lower in treated group than those in control group before PCI and at 12 h and 24 h after PCI (all P ＜ 0.05).TIMI flow grading and TMPG flow grading were better in treated group than those in control group (all P ＜ 0.05).The incidence of nonreflow during PCI was lower in treated group than that in control group (P ＜ 0.05).The incidence of MACE was significantly lower in treated group than that in control group (P ＜ 0.05) 1 month after PCI.Conclusions Atorvastatin calcium pre-treatment can not only alleviate myocardial injury and inflammatory reaction,but also improve postoperative blood perfusion to a certain extent and reduce short-term incidence of MACE in ACS patients.关键词
阿托伐他汀钙/急性冠状动脉综合征/经皮冠状动脉介入治疗/预后Key words
Atorvastatin calcium/Acute coronary syndrome/Percutaneous coronary intervention/Prognosis分类
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陈德奎,葛水秀..阿托伐他汀钙预治疗在急性冠状动脉综合征患者PCI术中的应用价值[J].心脑血管病防治,2017,17(4):269-272,4.
