疑难病杂志2017，Vol.16Issue(10)：977-980,984,5.DOI:10.3969/j.issn.1671-6450.2017.10.002
美托洛尔缓释片对慢性心力衰竭患者炎性因子及心功能的影响
Effect of metoprolol sustained release tablet on inflammatory factor and cardiac function in patients with chronic heart failure
摘要
Abstract
Objectives To investigate the influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure.Methods From January 2015 to December 2015,a total of 120 CHF patients in New York Heart Association (NYHA) functional classes II to IV were enrolled and randomized divided into treatment group (n=60) and control group (n=60).All the patients were in stable situation after conventional drug treatment.The patients in treatment group underwent intensive heart rate control for target HR (55-60 bpm) through adjusting the dose of metoprolol sustained release tablets.The resting heart rate was measured at the beginning,1 month and 12 months after treatment.The concentration of C reaction protein (CRP),interleukin 1β(IL-1β),interleukin 6 (IL-6),tumor necrosis factorα(TNF-α) were detected before and after 1 month treatment.The concentration of brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic dimension (LVESD) was measured before and 12 months after treatment.Results After 1 month treatment,the resting heart rate and inflammatory factors (CRP,IL-1β,IL-6,TNF-α) levels of the patients in the treatment group decreased significantly compared with that of control group (t=2.07,t=2.26,t=1.99,t=2.03,t=2.14,P<0.05).After 12 months treatment,the resting heart rate of the patients in the treatment group decreased significantly compared with that of control group (t=4.22,P<0.01),the echocardiography parameters (LVEDD,LVESD) and the concentration of BNP of the patients in the treatment group decreased significantly (t=2.32,t=2.43,t=2.21,t=2.12,P<0.05),LVEF of treatment group increased significantly (P<0.05).Conclusion Metoprolol sustained release tablets can significantly decrease inflammatory factors (CRP,IL-1β,IL-6,TNF-α) levels and improve cardiac function in patients with chronic heart failure.关键词
美托洛尔/心力衰竭,慢性/炎性因子/脑钠肽/心功能Key words
Metoprolol/Heart failure,chronic/Inflammatory factor/Brain natriuretic peptide/Cardiac function引用本文复制引用
陆铭,蒋庆渊,刘春兰,刘莹莹,凌佳,阚丽虹,庄晓华,蔡振荣..美托洛尔缓释片对慢性心力衰竭患者炎性因子及心功能的影响[J].疑难病杂志,2017,16(10):977-980,984,5.基金项目
上海市浦东医院科学技术研究项目(201311) （201311）
