疑难病杂志2017，Vol.16Issue(10)：1067-1071,5.DOI:10.3969/j.issn.1671-6450.2017.10.025
分泌IL-17淋巴细胞在慢性阻塞性肺疾病发病机制中的作用研究进展
The role of interleukin 17 producing T lymphoid cells in the pathogenesis of COPD
摘要
Abstract
During T cell receptor (TCR) activation in a particular cytokine environment,naive CD4+T cells may differentiate into lineages defined by their pattern of cytokine production and transcription factors: T helper 1(Th1),Th2,Th17,Th22,follicular helper T cells (Tfh) and inducible regulatory T cells (Treg).Although Th17 cells have only recently been recognized as a distinct lineage of Th cells,associations between interleukin (IL) 17 and human disease have been known somewhat longer.It would be oversimplification to restrict IL-17 to Th17.Some researches show that IL-17 is also expressed by other cells including CD8+T cells,γδT cells,Natural Killer (NK)T 17,lymphoid tissue induced (LTi) 17 and innate lymphoid cell (ILC) 17.IL-17 as a cytokine expressed by T cells,exerting inflammatory effects on epithelial,endothelial and fibroblast cells.IL-17 is a solid link between innate and adaptive immunity and can exert both beneficial as well as deleterious effects.However,it is little understood about associations between interleukin (IL) 17 and human disease.How does IL-17 participate in host defense,immune adjustment and automatic immune function remains to be further investigated.This paper aim to review the role of various cells secreting IL-17 T lymphoid cyte in COPD.关键词
CD4+T亚群/辅助性T细胞17/白介素17/固有淋巴细胞-17Key words
CD4+T cells/Th17/Interleukin 17/ILC17引用本文复制引用
查干..分泌IL-17淋巴细胞在慢性阻塞性肺疾病发病机制中的作用研究进展[J].疑难病杂志,2017,16(10):1067-1071,5.基金项目
湖北省卫生与计划生育委员会项目资助 (sj-201209) （sj-201209）
