中风与神经疾病杂志2017，Vol.34Issue(8)：700-702,3.
α-硫辛酸对糖调节受损大鼠认知功能和氧化应激影响的初步研究
A preliminary study of the effects of α-lipoic acid on cognitive function and oxidative stress in rats with impaired glucose regulation
周丽娜 1王洪新 1梁佩芬 1程焱2
作者信息
- 1. 天津医科大学第四中心临床学院神经内科,天津 300140
- 2. 天津医科大学总医院神经内科,天津 300052
- 折叠
摘要
Abstract
Objective To study the effects of lipoic acid on cognitive function and oxidative stress in rats with impaired glucose regulation.Methods Male Wistar rats were randomly divided into 5 groups:control group,model group,lipoic acid low 15 mg/(kg/d),medium 30 mg/(kg/d),high 60 mg/(kg/d) dose group.A rat model of impaired glucose regulation was established by feeding with high fat and high sugar diet.The model rats were fed with lipoic acid solution 15,30 and 60 mg/kg daily,1 times daily,with a total of 14 d.The learning and memory abilities of rats were measured by Morris water maze method,and the content of ROS in hippocampus of rats in each group was detected by flow cytometry.Results Compared with the control group,the learning and memory ability of the model group decreased (P<0.05),while the level of ROS in the hippocampus increased (P<0.05).Compared with the model group,the level of ROS in the brain decreased in the lipoic acid group,and the learning and memory ability of the rats increased,especially in the middle dose group (P<0.05).Conclusion Lipoic acid has protective effects on cognitive function in rats with impaired glucose regulation,and its protective effects are related to its antioxidant effects.关键词
糖调节受损/α-硫辛酸/认知功能/氧化应激Key words
Mpaired glucose regulation/α-lipoic acid/Cognitive function/Oxidative stress分类
医药卫生引用本文复制引用
周丽娜,王洪新,梁佩芬,程焱..α-硫辛酸对糖调节受损大鼠认知功能和氧化应激影响的初步研究[J].中风与神经疾病杂志,2017,34(8):700-702,3.
