中国耳鼻咽喉颅底外科杂志2017，Vol.23Issue(4)：370-373,4.DOI:10.11798/j.issn.1007-1520.201704018
鼓室注射甲强龙补救治疗全聋型突聋的临床分析
Clinical analysis of intratympanic methylprednisolone injection as salvage treatment for total sudden deafness after initial treatment failure
张宇 1高中 1刘亚军 1杨皖菁 1周波 1李丹 1肖键 1王勇1
作者信息
- 1. 湖北医药学院附属东风医院耳鼻咽喉头颈外科,湖北十堰442000
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of intratympanic methylprednisolone injection for total sudden deafness after initial treatment failure as salvage treatment.Methods 55 patients with diagnosis of total sudden deafness,who failed in responding to a two-week course of initial treatment,were divided into experimental group (intratympanic methylprednisolone injection plus oral administration of mecobalamine,n =26) and control group (oral administration of mecobalamine,n =29).Pure-tone threshold audiometry was performed within 4 weeks after the salvage treatment.Results The average pure-tone threshold (APT) and APT improvement of the experimental group were 59.88± 9.54 dB and 18.08 ± 10.06 dB respectively,while those of the control group were 67.62 ± 7.63 dB and 11.48 ± 6.34 dB.Both differences of APT and APT improvement between the two groups were statistically significant (both P ＜ 0.05).The obvious effective and total effective rates of the experimental group were 30.77％ (8/26) and 46.15％ (12/26),and those of the control group were 6.89％ (2/29) and 10.34％ (3/29).The differences of the obvious effective and total effective rates between the two groups were also statistically significant (both P ＜ O.05).Conclusion Intratympanic methylprednisolone injection is beneficial as salvage treatment for total sudden deafness failed in responding to initial treatment.关键词
突发性耳聋/甲强龙/鼓室注射/补救治疗Key words
Sudden deafness/Methylprednisolone/Intratympanic injection/Salvage treatment分类
医药卫生引用本文复制引用
张宇,高中,刘亚军,杨皖菁,周波,李丹,肖键,王勇..鼓室注射甲强龙补救治疗全聋型突聋的临床分析[J].中国耳鼻咽喉颅底外科杂志,2017,23(4):370-373,4.
