摘要
Abstract
Objective To investigate the distribution and drug resistance character of pathogenic microorganism in patients of pulmonary tuberculosis complicated with pneumonia and to improve their curative effect Methods Of 1025 cases of tuberculosis patients hospitaled Select from March 2011 to December 2015 were selected and 1043 pathogens microorganism were isolated.There were 768 males (74.9%) and 257 females (25.1%).Among them, 415 patients were <60 years old, 610 patients were ≥60 years old, and 18 patients were infected with multiple pathogens.Bacteria identification and drug sensitivity test (DST) were done by the United States BD Company PHOENIX-100 Automatic microbiological identification in 1043 clinical isolates.The data of DST was analyzed by WHONET 5.4 software.Results Among the 1043 pathogens, There were 83.3% (869/1043) gram-negative bacilli, 11.2% (117/1043) Gram-positive cocci, and 5.5% (57/1043) Fungal.The top five strains of Gram-negative bacilli were as follows: Pseudomonas aeruginosa, was 24.8% (259/1043);Acinetobacter baumannii was 16.9% (176/1043);Klebsiella pneumoniaewas 16.8% (175/1043);Stenotrophomonas maltophilia,was 8.4% (88/1043);Escherichia coli, was 7.4% (77/1043).Coagulase-negative staphylococci (6.0%, 63/1043) which were 100.0% (63/63) prednisone-resistant,and Staphylococcus aureus (4.1%, 43/1043) which were 67.4% (29/43) prednisone-resistant were predominant in Gram-positive cocci;vancomycin-resistant staphylococci were not found.Of 3.8% (40/1043) fungal infection were Candida albicans.DST showed: Pseudomonas aeruginosa had low resistance rates to meropenem (10.8%, 28/259), amikacin (3.5%, 9/259) and gentamicin (9.3%, 24/259).The resistance rate of Acinetobacter baumannii to amikacin (46.0%, 81/176), imipenem (45.5%, 80/176) and meropenem (47.7%, 84/176) was low.The resistance rates of meropenem in Klebsiella pneumoniae and Escherichia coli were (3.4%, 6/175) and (3.9%, 3/77),respectively and both of them were sensitive to carbapenems.Streptococcus maltophilia had a low resistance rate to chloramphenicol (25.0%, 22/88), cotrimoxazole (20.5%, 18/88) and levofloxacin (21.6%, 19/88).Conclusion Gram-negative bacilli is the common bacteria co-infection the hospitaled tuberculosis patients, rational antibiotic should be selected by DST in order to improve the therapeutic effect.关键词
结核,肺/重叠感染/抗药性,细菌/微生物敏感性试验/数据说明,统计Key words
Tuberculosis,pulmonary/Mixed infection/Drug resistance,bacterial/Microbial sensitivity test/Data interpretation,statistical
