中国普通外科杂志2017，Vol.26Issue(8)：1019-1029,11.DOI:10.3978/j.issn.1005-6947.2017.08.010
早期不同时间点行腹腔镜胆囊切除术治疗急性结石性胆囊炎疗效及安全性的Meta分析
Efficacy and safety of laparoscopic cholecystectomy in treatment of acute calculous cholecystitis at different timing within early stage: a Meta-analysis
摘要
Abstract
Objective:To compare the efficacy and safety of laparoscopic cholecystectomy (LC) in treatment of acute calculous cholecystitis (ACC) at different timing within early stage.Methods:The literature of clinical studies comparing the efficacy and safety of LC at different timings for ACC publically published before April 2017 was searched from national and international databases.Meta-analysis was performed on some relevant clinical variables by using RevMan 5.3 software.Results:Fifteen studies were included,involving 16 389 patients,of whom,13 417 cases underwent LC within 48 h after onset and 2 972 cases underwent LC within 48 to 72 h after onset.The results of Meta-analysis showed that,the operative time (MD=-1 1.33,95％ CI=-17.26--5.40,P=0.0002),intraoperative blood loss (MD=-24.60,95％ CI=-45.83--3.36,P=0.02),incidence of bile duct injury (OR=0.48,95％ CI=0.26 0.90,P=0.02) and open conversion rate (OR=0.56,95％ CI=0.43-0.74,P＜0.0001) were reduced in patients undergoing LC within 48 h compared with those undergoing LC within 48 to 72 h.The differences in the length of hospital stay,overall incidence of complications and the incidence of bile leakage,intestinal obstruction,postoperative intra-abdominal hemorrhage,wound infection,abdominal infection,pulmonary infection and incisional hernia showed no statistical significance between the two groups of patients (all P＞0.05).Conclusion:In ACC patients,LC has better efficacy and safety when performing within 48 h after onset.关键词
胆囊炎,急性/胆囊结石病/胆囊切除术,腹腔镜/Meta分析Key words
Cholecystitis, Acute/Cholecystolithiasis/Cholecystectomy, Laparoscopic/Meta-Analysis分类
医药卫生引用本文复制引用
孙明明,范逸怡,党胜春..早期不同时间点行腹腔镜胆囊切除术治疗急性结石性胆囊炎疗效及安全性的Meta分析[J].中国普通外科杂志,2017,26(8):1019-1029,11.基金项目
江苏省“六大人才高峰”高层次人才资助项目(2016-WSN-007). （2016-WSN-007）
