中国全科医学2017，Vol.20Issue(27)：3360-3367,8.DOI:10.3969/j.issn.1007-9572.2017.27.008
E-钙黏蛋白和波形蛋白的表达情况与结肠癌相关临床病理因素的关联性及其对患者预后的影响
Correlation of the Expressions of E-cadherin and Vimentin with the Clinicopathological Factors and Prognosis of Colon Cancer
摘要
Abstract
Objective The development of tumor is a complex pathophysiological process involving many interrelated factors.The purpose of this study was to investigate the correlation of the expressions of epithelial mesenchymal transition(EMT) markers(E-cadherin and Vimentin) with the clinicopathological factors and prognosis of colon cancer.Methods Immunohistochemistry with SP method was performed to detect the expressions of E-cadherin and Vimentin in the colon cancer and adjacent tissue specimens taken from 116 stage Ⅲ colon cancer patients who underwent radical resection of colon cancer in Department of Gastrointestinal Surgery of Affiliated Tumor Hospital of Xinjiang Medical University from January 1,2009 to January 1,2014 and pathologically diagnosed as colon cancer postoperatively.The patients were followed up by outpatient or ward review,telephone and so on with a deadline of January 1st 2015.Totaled 92.2% of the participants(107/116) were followed up for 4.1-63.0 months with a median follow-up of 46.0 months.Overall survival(OS) and disease-free survival(DFS) of patients were recored.Multivariate Logistic regression analysis was performed to investigate the correlation of the expressions of E-cadherin and Vimentin with the clinicopathological factors of colon cancer.Kaplan-Meier survival analysis was conducted to estimate the survival function.Survival rate was compared with the Log-rank test.Results The positive rate of E-cadherin and Vimentin expressions in all the participants was 79.3%(92/116),15.5%(18/116),respectively.The positive rates of E-cadherin of carcinoembryonic antigen(CEA),tumor diameter,vascular invasion,differentiation degree of colon cancer cells,lymphatic metastasis showed significant differences(P<0.05).The positive rates of Vimentin of tumor diameter,vascular invasion,perineural invasion,differentiation degree of colon cancer cells,lymphatic metastasis showed significant differences(P<0.05).Multivariate Logistic regression analysis found that CEA,vascular invasion and differentiation degree of colon cancer cells were significantly associated with the expression of E-cadherin(P<0.05).Vascular invasion,nerve invasion and differentiation degree of colon cancer cells were significantly associated with the expression of vimentin(P<0.05).Notable differences were found in the cumulative OS and DFS between E-cadherin positive group and negative group(P<0.05).The cumulative OS and DFS differed significantly between Vimentin positive group and negative group(P<0.05).Conclusion CEA,vascular invasion and the differentiation degree of colon cancer cells are the associated factors for the expression of E-cadherin.Vascular invasion,nerve invasion and the differentiation degree of colon cancer cells are the associated factors for the expression of Vimentin.E-cadherin and Vimentin are important adverse prognostic factors in colon cancer.关键词
结肠肿瘤/上皮-间质转化/钙黏着糖蛋白类/波形蛋白/预后Key words
Colonic neoplasms/Epithelial-mesenchymal transition/Cadherins/Vimentin/Prognosis分类
医药卫生引用本文复制引用
曾祥岳,孙振强,王琦三,葛磊,王海江..E-钙黏蛋白和波形蛋白的表达情况与结肠癌相关临床病理因素的关联性及其对患者预后的影响[J].中国全科医学,2017,20(27):3360-3367,8.基金项目
新疆维吾尔自治区自然科学基金(201233146-13) （201233146-13）
