中国全科医学2017，Vol.20Issue(27)：3377-3381,5.DOI:10.3969/j.issn.1007-9572.2017.27.011
脑脊液白介素8、干扰素γ水平在结核性脑膜炎病程中的动态变化及意义
Dynamic Changes in IL-8 and IFN-γ in Cerebrospinal Fluid of Patients with Tuberculous Meningitis
摘要
Abstract
Objective To observe the dynamic changes of IL-8 and IFN-γ in cerebrospinal fluid(CSF) of tuberculous meningitis(TBM),and to investigate their significance for the diagnosis and prognosis of TBM.Methods The subjects enrolled in this study were 30 inpatients with TBM(TBM group),30 inpatients with viral meningitis(viral meningitis group),30 inpatients with noninfectious neurologic diseases(noninfectious neurologic diseases group) treated in Lanzhou University Second Hospital from December 2014 to August 2016.There were 12 patients of stage Ⅰ,11 patients of stage Ⅱ,7 patients of stage Ⅲ in the TBM group.The changes of IL-8,IFN-γ levels in CSF of TBM group before antituberculosis treatment,1 week and 2 weeks after antituberculosis treatment were analyzed.The IL-8 and IFN-γ levels in CSF of TBM group before antituberculosis treatment,viral meningitis group and noninfectious neurologic diseases group before treatment were compared.The relation between the level of IL-8 and IFN-γ in CSF and the severity of the disease in TBM group was analyzed.Results The levels of IL-8 in CSF 1 week after antituberculosis treatment(t=15.710,P<0.001) and 2 weeks after antituberculosis treatment(t=21.268,P<0.001) were significantly lower than those before antituberculosis treatment in TBM group;the levels of IL-8 in CSF 2 weeks after antituberculosis treatment were significantly lower than those 1 week after antituberculosis treatment in TBM group(t=12.554,P<0.001).The levels of IFN-γ in CSF 1 week after antituberculosis treatment(t=10.793,P<0.001) and 2 weeks after antituberculosis treatment(t=14.357,P<0.001) were lower compared with those before antituberculosis treatment in TBM group;the levels of IFN-γ in CSF 2 weeks after antituberculosis treatment were lower compared with those 1 week after antituberculosis treatment in TBM group(t=17.979,P<0.001).The levels of IL-8 and IFN-γ in CSF of TBM group before antituberculosis treatment were significantly higher than those of viral meningitis group and noninfectious neurologic diseases group before treatment(P<0.05),and the levels of IL-8 and IFN-γ in CSF of viral meningitis group before treatment were significantly higher than those of noninfectious neurologic diseases group before treatment(P<0.05).The level of IL-8(rs=0.509,P=0.004) and that of IFN-γ(rs=0.665,P<0.001) in CSF were positively correlated with the severity of TBM in TBM group.Conclusion Both the levels of IL-8 and IFN-γ in CSF of TBM group gradually decrease with the progress of treatment,and they are positively related to the TBM stage,so they may be used as the predictors for the assessment of the response rate and prognosis of the disease.关键词
结核,脑膜/白细胞介素类/干扰素γ/脑脊液Key words
Tuberculosis/meningeal/Interleukins/Interferon-gamma/Cerebrospinal fluid分类
医药卫生引用本文复制引用
张帅杰,王满侠,李晓玲,王琪..脑脊液白介素8、干扰素γ水平在结核性脑膜炎病程中的动态变化及意义[J].中国全科医学,2017,20(27):3377-3381,5.基金项目
甘肃省兰州市城关区科技发展计划项目(2015-3-3) （2015-3-3）
