中国现代医学杂志2017，Vol.27Issue(19)：17-21,5.DOI:10.3969/j.issn.1005-8982.2017.19.004
3.0 T MRI表观扩散系数诊断中度肝纤维化价值的实验研究
Experimental study of apparent diffusion coefficient from 3.0 T MRI in identification of moderate liver fibrosis
摘要
Abstract
Objective To evaluate the value of apparent diffusion coefficient (ADC) from 3.0 T MRI DWI in identifying moderate liver fibrosis.Methods Rat model of hepatic fibrosis was established by intraperitoneal injection of porcine serum.The ADC values of the three groups were calculated when b value was 800 s/mm2.The rats were sacrificed quickly after DWI examination and then pathological examination was performed.The results of the control group,the mild liver fibrosis group (18 rats in S1 stage) and the moderate liver fibrosis group (22 rats in S2 and S3 stages) were compared by analysis of one-way ANOVA and SNK multiple comparison.ROC curve was used to determine the efficiency of ADC values in distinguishing moderate liver fibrosis from mild liver fibrosis.Results The ADC values of moderate and mild liver fibrosis were (1.47 ± 0.39)×10-3 mm2/s,(1.78 ± 0.67)×10-3 mm2/s respectively,significant difference was found between them.There was significant difference in the ADC value between the control group and the moderate liver fibrosis group,but no significant difference between the control group and the mild liver fibrosis group.The AUC of ADC in differentiating moderate liver fibrosis from mild liver fibrosis was 0.79,with the sensitivity of 61％ and the specificity of 100％ at the cut-off of 1.68×10-3 mm2/s.Conclusions 3.0 T MR DWI can reflect the microscopic changes of liver fibrosis in the early stage,the ADC value of the liver contributes to identification of moderate liver fibrosis.关键词
肝纤维化/大鼠/表观扩散系数/3.0T磁共振Key words
liver fibrosis/rat/ADC/3.0 T MRI分类
医药卫生引用本文复制引用
路洪剑,战跃福,李群,刘凡..3.0 T MRI表观扩散系数诊断中度肝纤维化价值的实验研究[J].中国现代医学杂志,2017,27(19):17-21,5.基金项目
海南省自然科学基金(No:817390) （No:817390）
