中国现代医学杂志2017，Vol.27Issue(19)：49-55,7.DOI:10.3969/j.issn.1005-8982.2017.19.010
新疆地区13100体检人群肾功能相关代谢物的异常状态:“分子水平亚健康”概念的现实临床意义
Abnormal blood levels of renal function-related metabolites among 13,100 physical examination population in Xinjiang: clinical significance of concept of Molecular Sub-healthy
阴慧慧 1马雅静 2刘斌正 1陈江 2李述刚 3张文杰1
作者信息
- 1. 石河子大学医学院病理系,新疆石河子832002
- 2. 石河子大学医学院第一附属医院检验科,新疆石河子832002
- 3. 石河子大学医学院预防医学系,新疆石河子832002
- 折叠
摘要
Abstract
Objective To examine fasting blood metabolites related to the renal function among individuals participating in the routine physical examinations and investigate their possible Molecular Sub-healthy status defined by having abnormal blood metabolites without relevant clinical manifestations or diagnosis.Methods Totally 13,100 individuals of Han Chinese attending heahh checkup in our clinic from January 2013 to August 2014 were tested for blood metabolites and activities related to the renal function after overnight fasting.The examination indexes including uric acid (UA),blood urea nitrogen (BUN),creatinine (CR) and cystatin-C (Cyst-C) were detected using an automated bioanalyzer.Results According to Chinese reference ranges for the 4 blood metabolites,the rates of increased levels of UA,BUN,Cyst-C and Cr were 14.05％,1.90％,0.82％ and 0.33％ respectively.The vast majority (＞ 80％) of the individuals with abnornal blood metabolites was clustered in 21-50 years of age in both genders,who formed the prime labor force in China.Blood levels of all the 4 metabolites in the males were higher than those in the females (P ＜ 0.05).The levels of BUN,Cyst-C and CR,but not UA,were positively correlated with age in both sexes.Conclusions This is the first investigation using a large sample of Han nationals presenting no clinical symptoms at the physical examination in Shihezi area,Xinjiang.Elevated levels of 4 renal function-related blood metabolites are found and we accordingly propose for the first time a concept of renal function-related Molecular Sub-healthy status,which serves as a pre-warning for asymptomatic renal diseases.Such a concept may be useful in preventive public health for those sub-healthy individuals at molecular level.关键词
健康体检/肾功能/肾功能相关代谢物/分子水平亚健康/公共卫生政策Key words
physical examination/renal function/renal function-related metabolites/Molecular Sub-healthy status/preventive public health policy分类
医药卫生引用本文复制引用
阴慧慧,马雅静,刘斌正,陈江,李述刚,张文杰..新疆地区13100体检人群肾功能相关代谢物的异常状态:“分子水平亚健康”概念的现实临床意义[J].中国现代医学杂志,2017,27(19):49-55,7.
