中国药科大学学报2017，Vol.48Issue(4)：407-415,9.DOI:10.11665/j.issn.1000-5048.20170404
蛋白质中氨基酸外消旋化的研究进展
Advances in racemization of protein amino acid
张欣然 1李博 2狄斌3
作者信息
- 1. 中国药科大学药物分析学教研室,南京210009
- 2. 中国药科大学蛋白质化学与结构生物学重点实验室,南京210009
- 3. 中国药科大学药物质量与安全预警教育部重点实验室,南京210009
- 折叠
摘要
Abstract
The presence of D-amino acid in proteins is thought to be a result of racemization of L-amino acid,which may influence the space structure and the functions of proteins and the connection to the occurence of some diseases has been demonstrated.Recently,tremendous advancement in instrumental techniques has brought the rapid development to analytical methods and detecting techniques in the research on racemization of protein amino acid.The advances in the relationship between racemizadon of protein amino acid and diseases,the influence factors on racemization of protein amino acid and the analytical techniques are reviewed in this article,and the research directions of racemization of protein amino acid are also given.关键词
蛋白质/氨基酸/外消旋化/影响因素/检测方法/进展Key words
protein/amino acid/racemization/influence factors/detecting techniques/advances分类
医药卫生引用本文复制引用
张欣然,李博,狄斌..蛋白质中氨基酸外消旋化的研究进展[J].中国药科大学学报,2017,48(4):407-415,9.
