中国药房2017，Vol.28Issue(25)：3483-3486,4.DOI:10.6039/j.issn.1001-0408.2017.25.08
不同产地和叶形附子水煎液的抗炎、镇痛作用比较
Comparison of the Anti-inflammation,Analgesic Effects of Decoctions Extracted from Aconiti Lateralis with Different Leaf Shapes from Different Producing Areas
摘要
Abstract
OBJECTIVE:To compare the anti-inflammation,analgesia effects of decoctions extracted from Aconiti lateralis with different leaf shapes(dahua leaf,xiaohua leaf)from different producing areas(Jiangyou,Butuo). METHODS:Animals were randomly divided into blank group(distilled water),positive group,groups of Aconiti lateralis with dahua,xiaohua leaf from Ji-angyou,groups of Aconiti lateralis with dahua,xiaohua leaf from Butuo(with dose of 5 g/kg,calculated by crude drug). The an-ti-inflammation effect of decoctions extracted from Aconiti lateralis with different variety sources and leaf shapes was investigated by xylene-induced ear swelling test (n=12) in mice and egg white-induced toe swelling test (n=10) in rats (positive drug was Dexamethasone acetate tablet,0.005 g/kg). And its analgesic effect was investigated by acetic acid-induced writhing body reaction test(n=12)and hot-plate-induced pain test(n=12)in mice(positive drug was Morphine hydrochloride tablet,0.0025 g/kg). RE-SULTS:The decoctions extracted from Aconiti lateralis with dahua,xiaohua leaf from Butuo and xiaohua leaf from Jiangyou can significantly reduce the ear swelling degree(P<0.01). The decoctions extracted from Aconiti lateralis with dahua leaf from Jiangy-ou and Butuo can significantly decrease the toe swelling degree after 6 h of medication(P<0.05). And decoctions extracted from Aconiti lateralis with xiaohua leaf from Butuo can significantly reduce the number of writhing body in mice with acetic acid-in-duced pain and prolong the pain threshold of mice with hot-plate-induced pain (P<0.05 or P<0.01). CONCLUSIONS:Aconiti lateralis with dahua and xiaohua leaf from Butuo and with xiaohua leaf from Jiangyou show better anti-inflammation effect,and Aconiti lateralis with xiaohua leaf from Butuo shows better analgesic effect.关键词
产地/附子/叶形/抗炎/镇痛Key words
Producing areas/Aconiti lateralis/Leaf shapes/Anti-inflammation/Analgesia分类
医药卫生引用本文复制引用
缪璐琳,熊秋韵,高继海,李梦婷,敖慧,谢晓芳,彭成..不同产地和叶形附子水煎液的抗炎、镇痛作用比较[J].中国药房,2017,28(25):3483-3486,4.基金项目
国家基础科学人才培养基金资助项目(No. J1310034) （No. J1310034）
国家自然科学基金资助项目(No.81630101) （No.81630101）
国家中药标准化项目(No.ZYBZH-C-SC-51) （No.ZYBZH-C-SC-51）
四川省中医药科学技术研究专项项目(No.2016ZY008) （No.2016ZY008）
四川省科技厅项目(No.2013SZ0114) （No.2013SZ0114）
四川省青年科技创新研究团队专项计划项目(No.2015TD0028) （No.2015TD0028）
四川省科技计划项目(No.2014SZ0156) （No.2014SZ0156）
