中国药房2017，Vol.28Issue(25)：3502-3505,4.DOI:10.6039/j.issn.1001-0408.2017.25.13
天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响
Effect of Natural Emulsifier Acacia Senegal on in vivo and in vitro Performance of Chlorogenic Acid Self-microemulsion
摘要
Abstract
OBJECTIVE:To study the effect of natural emulsifier acacia senegal on in vivo and in vitro performance of chloro-genic acid self-microemulsion. METHODS:Chlorogenic acid self-microemulsion containing acacia senegal("new chlorogenic acid self-microemulsion")was prepared by using acacia senegal to gradually replace polysorbate 80 in chlorogenic acid self-microemul-sion containing nonionic emulsifier ("traditional chlorogenic acid self-microemulsion"). The appearance,morphology,particle size,conductivity,pH value,stability,in vitro release and intestinal absorption kinetics of the 2 kinds self-microemulsions were evaluated. RESULTS:50％of polysorbate 80 was replaced by acacia senegal in new chlorogenic acid self-microemulsion. The tradi-tional and new chlorogenic acid self-microemulsions had clear appearance,and approximately spherical drops. Particle sizes were (24.53 ± 3.03),(35.51 ± 5.91) nm;dectrical conductivities were (195.6 ± 0.3),(189.5 ± 0.4)μs/cm;and pH were 3.87 ± 0.02, 4.08 ± 0.03 (n=3),respectively. Compared with traditional chlorogenic acid self-microemulsion,the absorption rate constant,ef-fective permeability coefficient and absorption amount of the new one in duodenum,jejunum,ileum were increased a little (P>0.05);the above indexes in colon were obviously decreased (P<0.05). CONCLUSIONS:The new chlorogenic acid self-micro-emulsion can maintain the performance of traditional one,and increase absorption of chlorogenic acid in small intestine.关键词
阿拉伯胶/绿原酸/自微乳/粒径/体外释放度Key words
Acacia senegal/Chlorogenic acid/Self-microemulsion/Particle size/in vitro release分类
医药卫生引用本文复制引用
陈莉,侯成贤,杨燕飞..天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响[J].中国药房,2017,28(25):3502-3505,4.基金项目
贵州省科学技术基金项目(No.黔科合J字LKZ〔2013〕26号) （No.黔科合J字LKZ〔2013〕26号）
