中国药理学通报2017，Vol.33Issue(10)：1338-1341,4.DOI:10.3969/j.issn.1001-1978.2017.10.002
内皮间质转分化在动脉粥样硬化中的研究进展
Research progress of endothelial mesenchymal transition in atherosclerosis
摘要
Abstract
Endothelial to mesenchymal transition(EndMT) plays a major role during organism development, and also contributes to several adult cardiovascular diseases.EndMT-derived fibroblast-like cells are common in atherosclerotic lesions.Pro-atherosclerosis factors, such as oxidative stress, hypoxia, inflammatory cytokines and oscillatory fluid shear stress can promote EndMT.EndMT is closely associated with plaque calcification, and unstable and ruptured plaque phenotype that may prone to cause clinical events.EndMT may be another key step in the prevention and treatment of atherosclerosis.Here, we reviewed the role played by endothelial-to-mesenchymal transition(EndMT) and its key regulators in atherosclerosis.关键词
动脉粥样硬化/内皮间质转分化/钙化/不稳定斑块/非编码RNA/通心络Key words
atherosclerosis/endothelial-to-mesenchymal transition/calcification/unstable plaque/non-coding RNA/tongxinluo分类
医药卫生引用本文复制引用
李红蓉,秘红英,孙颖,常丽萍,魏聪,梁俊清..内皮间质转分化在动脉粥样硬化中的研究进展[J].中国药理学通报,2017,33(10):1338-1341,4.基金项目
国家重点基础研究发展计划(973计划)资助项目(No 2012CB518606) （973计划）
