中国药理学通报2017，Vol.33Issue(10)：1342-1344,3.DOI:10.3969/j.issn.1001-1978.2017.10.003
上皮间质转化的机制研究进展
Mechanism of epithelial-mesenchymal transition
摘要
Abstract
Epithelial-mesenchymal transition (EMT) is a process by which the epithelial cells change to a mesenchymal phenotype.The highly conserved and fundamental process is integral in development, wound healing and contributes pathologically to fibrosis and cancer progression.The process can be activated by many transcription factors, growth factors or protein molecules, which involves complex molecular mechanism and signal transduction pathways.This paper reviews the development of molecular mechanisms of epithelial-mesenchymal transition and briefly summarizes the research progress of natural compounds targeting the EMT.关键词
上皮间质转化/转录因子/生长因子/蛋白分子/分子机制/天然化合物Key words
epithelial-mesenchymal transition/transcription factor/growth factor/protein molecule/molecular mechanism/natural compound分类
医药卫生引用本文复制引用
李汉清,可燕..上皮间质转化的机制研究进展[J].中国药理学通报,2017,33(10):1342-1344,3.基金项目
上海市卫生局课题(No 20144Y0152) （No 20144Y0152）
上海市教委预算内课题(No 2015YSN25) （No 2015YSN25）
