中国药理学通报2017，Vol.33Issue(10)：1345-1349,5.DOI:10.3969/j.issn.1001-1978.2017.10.004
microRNA对药物体内过程调控的研究进展
The research progress of microRNA on regulation of drug disposition in vivo
李辉 1芮建中1
作者信息
- 1. 中国人民解放军南京总医院药理科,江苏 南京 210002
- 折叠
摘要
Abstract
The disposition of drug in vivo is subjected to a series of biotransformation and transport, depending on the involvement of drug-metabolizing enzymes and transporters.However, the individual capacity varies when metabolizing and transporting the same drug, and pharmacogenomics has trouble in completely explaining the differences.microRNA, a key aspect of epigenetic modifications, is a powerful complement to traditional genetics.Emerging evidences have confirmed that drug-metabolizing enzymes and transporters be controlled by different microRNAs, and the same microRNA also regulates several drug-metabolizing enzymes or/and transporters simultaneously.All of these researches infer that microRNAs are likely to realize the comprehensive macro-regulation of gene expression.The further study of microRNAs maybe a suitable point to research the interindividual variability in disposition of drugs, and it provides a theoretical basis for rational use of drug and individualized medicine.关键词
microRNA/表观遗传学/药物代谢酶/药物转运体/个体差异/合理用药Key words
microRNA/epigenetics/drug-metabolizing enzyme/drug transporter/interindividual variability/rational use of drug分类
医药卫生引用本文复制引用
李辉,芮建中..microRNA对药物体内过程调控的研究进展[J].中国药理学通报,2017,33(10):1345-1349,5.
