中国药理学通报2017，Vol.33Issue(10)：1353-1356,4.DOI:10.3969/j.issn.1001-1978.2017.10.006
氧化应激在酒精性肝病中作用机制的研究进展
Research progress in mechanism of oxidative stress in alcoholic liver disease
摘要
Abstract
Harmful substances are produced during the metabolism of alcohol in the human body, which causes liver disease.The mechanism of oxidative stress is the main pathogenesis of alcoholic liver disease, which plays a major role in the occurrence and development of alcoholic liver disease.Alcohol-induced oxidative stress mediated by reactive oxygen species(ROS)/reactive nitrogen species(RNS) brings about liver disease via apoptotic signaling pathway and MAPK signaling pathway, and alleviates liver disease through Nrf2 signaling pathway.In this paper, the studies on the mechanism of oxidative stress in alcoholic liver disease are reviewed.关键词
酒精代谢/氧化应激/酒精性肝病/信号通路/发病机制/肝损伤Key words
alcohol metabolism/oxidative stress/alcoholic liver disease/signaling pathway/pathogenesis/liver injury分类
医药卫生引用本文复制引用
夏婷,张瑾,姚佳慧,郑宇,宋佳,王敏..氧化应激在酒精性肝病中作用机制的研究进展[J].中国药理学通报,2017,33(10):1353-1356,4.基金项目
国家自然科学基金资助项目(No 81600126,31471722) （No 81600126,31471722）
国家高技术研究发展计划(863计划)资助项目(No 2013AA102106) （863计划）
国家重点研发计划(No 2016YFD0400505) （No 2016YFD0400505）
教育部"长江学者和创新团队发展计划"资助项目(No RT15R49) （No RT15R49）
天津市科技支撑计划项目(No 16YFZCNC00650) （No 16YFZCNC00650）
