中国药业2017，Vol.26Issue(17)：6-9,4.DOI:10.3969/j.issn.1006-4931.2017.17.002
何首乌抗性淀粉促进靶向结肠微丸体外药物释放研究
Study on Resistant Starch of Polygonum Multiflorum for Promoting Drug Release in Vitor of Targeted Colon Pellets
摘要
Abstract
Objective To investigate the feasibility of resistant starch ( RS ) of Polygonum multiflorum as a targeted colon pellet material. Methods Under the physiological conditions, the dissolution rate of RS and microcrystalline cellulose ( MCC ) in different proportions of pellets was investigated, with Matrine ( MT ) as the model drug, the pellets were prepared by extrusion-spheronization technology, and the relevant indexes were observed. Results RS had shown significant effect on the release of pellets. In vitro drug release showed that when the RS/MCC was less than 0. 5, the yield, sphericity and crispness of the pellets were > 80. 00％,> 0. 95 and < 0. 12％, respectively. High content of RS in pellets could significantly improve the tolerance to pH changes and enzymatic hydrolysis. Under the action of mi-crobial Escherichia coli, the pellets rapidly disintegrated and dissolved more than 82％ in 30 min. Conclusion RS of Polygonum multi-florum is a promising oral delivery system, which can exert efficacy in the colon target.关键词
抗性淀粉/结肠靶向/成型性/药物释放Key words
resistant starch/colonic targeting/moldability/drug release分类
医药卫生引用本文复制引用
李闻涛,万科,杨莹,阮婧华,曹佩雪,杨小生..何首乌抗性淀粉促进靶向结肠微丸体外药物释放研究[J].中国药业,2017,26(17):6-9,4.基金项目
国家自然科学基金[ 81360486 ] （）
贵州省中药现代化科技产业研究开发专项项目[黔科合SY字〔2014〕3081-2号]. （）
