中国药业2017，Vol.26Issue(17)：43-45,3.DOI:10.3969/j.issn.1006-4931.2017.17.014
恩替卡韦治疗不同乙型肝炎病毒基因型慢性乙型肝炎疗效分析
Efficacy of Entecavir in Treating Chronic Hepatitis B with Different Hepatitis B Virus Genotypes
范倩燕 1鲍彩丽 2俞莹 2陈颖 2夏明镜 2殷建华3
作者信息
- 1. 上海市杨浦区中医医院,上海 200090
- 2. 同济大学附属杨浦医院,上海 200065
- 3. 第二军医大学,上海 200433
- 折叠
摘要
Abstract
Objective To investigate the clinical effect of chronic hepatitis B with different hepatitis B virus ( HBV ) genotypes. Methods Totally 200 HVB patients admitted to Shanghai Yangpu Central Hospital ( Antu Branch ) from January 2012 to December 2014 were selected. After genotyping, the patients were treated with entecavir, the efficacy of different genotypes was observed. Results In the 24th week, the HBV DNA negative conversion rate of the B genotype was 82. 35％, and 73. 47％ of the C genotype. Meanwhile, the ALT recurrence rate was also higher, the B genotype was 78. 43％, and the C genotype was 70. 41％. Until the 96th week after treatment, the recurrence rates of ALT in patients with B and C genotypes were 81. 37％ and 71. 43％, respectively, and the negative conversion rates of HBV and DNA were 89. 22％ and 83. 67％, respectively, the negative transformation rates of HBeAg were 13. 73％ and 10. 20％, respectively, the seroconversion rates of HBeAg were 10. 78％ and 7. 14％, respectively. There was no significant difference in clinical efficacy in the 24th, 96th weeks ( P > 0. 05 ) . Conclusion Whether or not the genotype of HBV affects the antiviral effect of ente-cavir remains to be explored, in order to better understand the antiviral treatment and clinical efficacy of HBV.关键词
恩替卡韦/乙型肝炎病毒基因/慢性乙型肝炎Key words
entecavir/hepatitis B virus genotypes/chronic hepatitis B分类
医药卫生引用本文复制引用
范倩燕,鲍彩丽,俞莹,陈颖,夏明镜,殷建华..恩替卡韦治疗不同乙型肝炎病毒基因型慢性乙型肝炎疗效分析[J].中国药业,2017,26(17):43-45,3.
