中国药业2017，Vol.26Issue(18)：8-10,3.DOI:10.3969/j.issn.1006-4931.2017.18.003
非洛地平缓释片体外多pH溶出方法建立的研究
Establishment of in Vitro Multi-pH Dissolution Method for Felodipine Sustained Release Tablets
祁飞 1张晨光 1马悦1
作者信息
- 1. 石家庄以岭药业股份有限公司,河北石家庄 050035
- 折叠
摘要
Abstract
Objective To establish an in vitro dissolution method to stimulate the gastrointestinal pH in vivo. Methods Felodipine Sus-tained Release Tablets were taken as the research object to investigate the in vitro release behavior of the self-made tablets and the original tablets in different dissolution conditions,and f2 factor was taken as the evaluation index. Results In the single dissolution medium of pH=1. 2 and pH=6. 5,the f2 factor between the self-made and the reference tablets was less than 50. But after the pH of the medium in the process of dissolution was changed with the pH adjuster;the release equation of the two were both in accordance with the peppas equation,and the f2 value was 61. 1. Conclusion The method of in vitro dissolution of simulated gastric gastrointestinal pH can simulate the release behavior of drugs more accurately,and more scientific and reasonable than traditional dissolution method.关键词
非洛地平缓释片/体外溶出/酸碱度Key words
Felodipine Sustained Release Tablets/in vitro dissolution/pH分类
医药卫生引用本文复制引用
祁飞,张晨光,马悦..非洛地平缓释片体外多pH溶出方法建立的研究[J].中国药业,2017,26(18):8-10,3.
