中国药业2017，Vol.26Issue(18)：27-29,3.DOI:10.3969/j.issn.1006-4931.2017.18.009
重组人碱性成纤维细胞生长因子雾化吸入用于全身麻醉下颈椎前路术后咽喉痛30例疗效观察
Clinical Observation of Aerosol Inhalation of Recombinant Human Basic Fibroblast Growth Factor for Treating Sore Throat After Anterior Cervical Operation Under General Anesthesia in 30 Cases
摘要
Abstract
Objective To observe the clinical efficacy of aerosol inhalation of recombinant human basic fibroblast growth factor (rh-bFGF)for treating sore throat after anterior cervical operation under general anesthesia. Methods Totally 60 patients underwent anterior cervical operation under general anesthesia and removed tracheal catheters were randomly divided into the treatment group and the control group. The treatment group was given rh-bFGF 35000 U + 0. 9% Sodium Chloride Injection 20 mL,compression inhalation,1 time a day,20 min for each time,the drugs were continuously used for 3 days. The control group was given 0. 9% Sodium Chloride Injection 5 mL + dexamethasone 5 mg + gentamicin 80000 U + chymotrypsin 4000 U,compression inhalation,twice a day,20 min for each time,the drugs were continuously used for 3 days. Results 12,24,48,72 h after operation,the incidence of sore throat and VAS score of sore throat (swallowing)of the treatment group were significantly lower than those of the control group (P < 0. 05). Conclusion Aerosol inhalation of rh-bFGF can obviously promote the repair of respiratory tract mucous membrane,reduce bleeding and bronchial stenosis and other complications,in order to reduce the incidence of sore throat and the degree of pain after anterior cer-vical operation under general anesthesia,it is worthy of promotion.关键词
重组人碱性成纤维细胞生长因子/雾化吸入/经颈椎前路术/全身麻醉/术后咽喉痛/气管插管/临床疗效Key words
recombinant human basic fibroblast growth factor/aerosol inhalation/anterior cervical operation/general anesthesia/postoperative sore throat/trachea cannula/clinical effect分类
医药卫生引用本文复制引用
刘斌,戴仁峰,金掌,甘维,傅江涛..重组人碱性成纤维细胞生长因子雾化吸入用于全身麻醉下颈椎前路术后咽喉痛30例疗效观察[J].中国药业,2017,26(18):27-29,3.基金项目
国家卫生计生委科技中心重大疾病防治科技行动计划项目[2016ZX-01-011] （）
浙江省丽水市高层次人才培养资助项目[2014RC26]. （）
