中国药业2017，Vol.26Issue(18)：82-85,4.DOI:10.3969/j.issn.1006-4931.2017.18.030
458例氨茶碱注射液不良反应/事件报告分析
Analysis of 458 Reports of Adverse Drug Reactions/Events Induced by Aminophyiline Injection
摘要
Abstract
Objective To promote clinical safety and rational use of drugs. Methods The general rules and characteristics of 458 cases of ADR/ADE related to the Aminophyiline Injection from 2012 to 2016 in Henan province were analyzed retrospectively. The instructions of similar products in China and America were compared in order to find similarities and differences. Results In the reports,men were slightly more likely than women ,and over 65 years old patients were more than other ages (43. 67%),58. 30% ADR / ADE occurred within 30 min. The most common ADR/ADE was nausea (26. 80%),followed by vomiting (17. 37%),the main organs involved were gastrointestinal system damage (49. 13%),heart rate and arrhythmia (11. 29%),and mental disorder (10. 30%). The higher the serum theophylline concentration,the serious the degree of ADR/ADE,particularly the potentially irreversible brain injury, lethality arrhythmia and convulsion,and the risk of death. Conclusion It is important to pay attention to the ADR/ADE induced by Aminophyiline Injection,improve the safety information of the instructions,strengthen the ability of early warning and monitoring,and improve the level of clinical safety and rational drug use.关键词
氨茶碱注射液/药品不良反应/药品不良事件/合理用药Key words
Aminophylline Injection/adverse drug reaction/adverse drug event/rational drug use分类
医药卫生引用本文复制引用
马雪皎,刘超,王长之,杨雪..458例氨茶碱注射液不良反应/事件报告分析[J].中国药业,2017,26(18):82-85,4.基金项目
河南省科技攻关项目[162102310379]. （）
