中国真菌学杂志2017，Vol.12Issue(4)：203-206,4.
维拉帕米增加伊曲康唑体外抗烟曲霉能力
Verapamil enhances antifungal activity of itraconazole against Aspergillus fumigatus in vitro
摘要
Abstract
Objective To study the effect of verapamil on antifungal activity of itraconazole against Aspergillus fumigatus in vitro.Methods Colony diameters were measured to compare the drug sensitivity when the strains were inoculated on the media with itraconazole alone and in the combination of verapamil.Spore germination were observated by microscope under itraconazole alone and in the combination of verapamil.Testing for susceptibility to itraconazole was carried out by the brothbased microdilution and E-test methods.Results Colony growth and conidia germination and biofilms were inhibited better under the combination of itraconazole and verapamil than that under itraconazole alone.Conclusions Verapamil enhances antifungal activity of itraconazole against Aspergillus fumigatus in vitro.关键词
烟曲霉/伊曲康唑/维拉帕米/抗菌Key words
Aspergillus fumigatus/itraconazole/verapamil/antifungal activity分类
医药卫生引用本文复制引用
陈培英,曾秋琼,孔庆涛,张征,张玲莉,曾梅华,桑红..维拉帕米增加伊曲康唑体外抗烟曲霉能力[J].中国真菌学杂志,2017,12(4):203-206,4.基金项目
国家自然科学基金(31500122) （31500122）
