中国真菌学杂志2017，Vol.12Issue(4)：207-211,5.
IL-22对口腔白念珠菌感染的保护作用及机制研究
The role of IL-22 in oral candidiasis which caused by Candida albicans
摘要
Abstract
Objective To evaluate the role of IL-22 in oral candidiasis which caused by Candida albicans.Methods We built the models of experimental oral candidiasis in BALB/c mice firstly.Then we used anti-IL-22 antibody to block the immune response.After that we estimate the manifestation of acute oral candidiasis and colonization of C.albicans in the tongue.Histopathological study and the cytokine changes of buccal mucosa were detected either.Results Mice which IL-22 were blocked showed thick pseudomembranous substance on the tongue and the fungal burden reached 1 700 CFU/mL.The normal mice showed thin pseudomembranous substance and the fungal burden was 980 CFU/mL.Histopathological examinations showed hyphae existing on the mucosal surface and invading epithelium accompanied by destruction of epithelium and inflammatory infiltration in the IL-22 blocked mice.Meanwhile,in the normal mice,there were less hyphae existing and rare inflammation.The Real-time PCR showed that compare with wild mice,the fold change of TNF-α,CXCL-9,CXCL-10,CXCL-11 in IL-22 blocked one were 18.1,0.8,1.2 and 0.9 times.Which were 34.5,1.2,6.1and 1.7 times in IL-22 normal mice.Conclusions IL-22 can be protective through enhance the secretion of chemotactic factor in oral candidiasis which caused by C.albicans.关键词
口腔念珠菌病/白念珠菌/IL-22Key words
Oral candidiasis/Candida albicans/IL-22分类
医药卫生引用本文复制引用
谭静文,何文婧,高志琴,杨虹,章楚光,梁豫琳,杨连娟..IL-22对口腔白念珠菌感染的保护作用及机制研究[J].中国真菌学杂志,2017,12(4):207-211,5.基金项目
上海市卫生和计划生育委员会面上项目(20140388) （20140388）
国家自然科学基金面上项目(81573063) （81573063）
