温淼 1杨波 1魏娜 1张婧 1闫婧 1濮月华 1杨中华1
作者信息
- 1. 100050 北京 首都医科大学附属北京天坛医院脑血管病中心神经重症医学科
- 折叠
摘要
Abstract
Objective To investigate the influence of Aspirin on the early development of acute respiratory distress syndrome (ARDS) incidence rate in patients with severe cerebrovascular disease. Methods This was a prospective cohort study. A total of 309 patients admitted to the neurologic intensive care unit (NICU) of our hospital within 48 hours after onset of severe cerebrovascular disease with a Glasgow Coma Scale (GCS) score ≤8 points were consecutively enrolled. Subjects of entry included sex, age, medical history, medication preceding onset, baseline score of GCS, primary disease, whether the patient underwent anesthesia and/or received craniotomy, early ARDS occurrence, mechanical ventilation time, length of stay in NICU, mortality rate, etc. The ARDS incidence rates of two groups were compared. Meanwhile, the clinical factors of patients of ARDS and non-ARDS groups were compared. Results There was a significant reduction of ARDS incidence rate in aspirin group (n=106) as opposed to non-aspirin group (n=203) 20.8％ vs 30.5％ (P=0.045). Patients of the aspirin group had a higher average age[(62.41±10.69) vs (57.40±14.80), P=0.002], a larger percentage of combined hypertension (50.9％ vs 38.4％, P=0.035), more coronary heart disease (31.1％ vs 20.2％, P=0.032), and higher rate of taking statins (26.4％ vs 8.4％, P=0.002). Ischemic stroke accounted for a larger proportion of the primary disease in this group. As opposed to non-ARDS group (223 cases), ARDS group (n=86) had lower GCS scores [(3.87±1.61) vs (6.48±1.51), P=0.043], less mechanical ventilation time [6 (5-8)d vs 0 (0-3)d, P=0.001], and required longer NICU stay [8 (6-10)d vs 3 (2-4)d, P=0.001], but had no significant difference in mortality rate. Conclusion Regular use of aspirin can reduce early ARDS incidence rate in severe cerebrovascular diseases, but cannot reduce mechanical ventilation time, duration of stay in NICU or morality rate.关键词
重症/脑血管病/急性呼吸窘迫综合征/阿司匹林Key words
Severe/Cerebrovascular disease/Acute Respiratory Distress Syndrome/Aspirin
