中国卒中杂志2017，Vol.12Issue(9)：786-789,4.DOI:10.3969/j.issn.1673-5765.2017.09.005
短暂性脑缺血发作患者血浆高半胱氨酸与尿酸水平相关性研究
The Levels and Correlation Studies of Homocysteine and Uric Acid in Plasma in Patients with Transient Ischemic Attack
摘要
Abstract
Objective To investigate the levels and correlation of homocysteine (HCY) and uric acid (UA) in blood plasma of patients with transient ischemic attack (TIA). Methods The blood preparation of 110 patients with TIA and 115 normal subjects were collected. The levels of HCY and UA were respectively measured by fluorescence immunoassay and colorimetry. Results The levels of the HCY and UA in plasma of TIA patients were (20.47±7.32) μmol/L and (341.17±84.31) μmol/L respectively. The levels of HCY and UA in the common group plasma were (15.28±4.62) μmol/L and (298.67±64.59) μmol/L respectively. The contents of the HCY and UA in plasma of TIA group were significantly higher than that of the common group (All P<0.001). The Pearson correlation analysis showed that there was a positive correlation between HCY and UA in plasma of TIA patients (r=0.239, P=0.012). Logistic regression analysis revealed that the UA [odds ratio (OR) 1.017, 95％ confidence interval (CI) 1.012-1.023, P<0.001] and HCY (OR 1.077, 95％CI 1.003-1.156, P=0.041)were the independent risk factors for TIA. Conclusion The contents of the HCY and UA in plasma of TIA group were both increased and were associated with each other.关键词
短暂性脑缺血发作/同型半胱氨酸/尿酸Key words
Transient ischemic attack/Homocysteine/Uric acid引用本文复制引用
赵兴军,刘芳,孟颖,魏巍,李一才,刘志辉,刘君玲..短暂性脑缺血发作患者血浆高半胱氨酸与尿酸水平相关性研究[J].中国卒中杂志,2017,12(9):786-789,4.基金项目
山东省自然科学基金(Wnt/β-catenin通路在辅酶Q保护高糖损伤的血管内皮细胞中作用的研究, ZR2015HL042)潍坊市科技技术发展计划项目(2015WS050)潍坊市卫生局科技项目(2014039) （Wnt/β-catenin通路在辅酶Q保护高糖损伤的血管内皮细胞中作用的研究, ZR2015HL042）
