TLR4/NF-κB通路在异氟醚预处理对大鼠心肌缺血再灌注损伤保护中的作用OACSTPCD
Isoflurane preconditioning protects myocardium after ischemic-reperfusion injury in rats through toll-like receptor 4/NF-κB signaling pathway
目的 探讨TLR4/NF-κB信号通路在异氟醚预处理对大鼠心肌缺血再灌注损伤保护中的作用,为防治心肌缺血/再灌注损伤提供新的理论依据.方法 将成年雄性SD大鼠40只随机分成5组:假手术组(S组)、缺血再灌注损伤组(IR组)、异氟醚预处理组(ISO组)、TLR4抑制剂TAK-242组(T组)、异氟醚+TAK-242预处理组(ISOT组),每组8只.S组左冠状动脉前降支只穿线不结扎;IR组只进行缺血再灌注;ISO组:吸入1.0MAC异氟醚30min,…查看全部>>
Objective To investigate the effect of isoflurane preconditioning on myocardium after ischemia/reperfusion (I/R) injury in rats and its relation to toll-like receptor 4 (TLR4)/NF-κB signaling pathway.Methods Forty SD rats were randomly divided into five groups with 8 in each:sham-operated group (group S),ischemia/reperfusion group (group IR),isoflurane preconditioning group(group ISO),TAK-242 inhibitor group(group T) and isoflurane preconditioning and TAK-24…查看全部>>
芦曼;陈永权
310006杭州,浙江省中医院麻醉科皖南医学院附属第一医院麻醉科
缺血再灌注损伤心肌保护异氟醚TLR4NF-κB
Ischemia reperfusion injuryIsofluraneMyocardial preservationToll-like receptor 4NF-κB
《浙江医学》 2017 (15)
1239-1242,4
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