摘要
Abstract
Objective To analysis of downregulating effect of different dosage of triptorelin (GnRHa),in vitro fertilization-embryo transfer (IVF-ET),to explore the best triptorelin injection dosage,looking for the best treatment for infertile patients.Methods A retrospective analysis of 379 IVF-ET cycle using luteal phase long acting,Divided them into three groups according to dose of GnRHa,GnRHa 0.6-1.0mg for group A (n=117),GnRHa 1.75-2.0mg for group B (n=65),GnRHa3.75mg for group C (n=197),compare the hormone level after downregulated and on day of HCG administration,Gn days and Gn dosage,oocyte numbers,laboratory data,implantation rate,pregnancy rate,abortion rate and the incidence of severe ovarian hyperstimulation syndrome.Results The LH level after downregulation (0.41 ±0.28)IU/L in group C was lower than that in group A (1.32 ±0.60) IU/L and group B (1.17 ± 0.51)IU/L(P＜0.05).LH level on the day of hCG administration in group A(0.98 ± 1.09)IU/L is significantly higher than that in group B (0.57 ± 0.30)IU/L and group C (0.62 ± 0.60)IU/L (P＜0.05).Gn using days in group B turned longest,longer than group C and group A,comparing one to each other statistically significant (P＜0.05),but the dosage of the Gn using have no statistical difference in three groups.Oocytes mature rate in group B and C was obviously higher than that of group A.Optimal embryo rate in group B was obviously higher than that in group A,while there was no significant difference compare to group C.There were no significant difference in oocyte numbers,normal fertilization rate,cleavage rate,implantation rate,clinical pregnancy rate,abortion rate and severe OHSS rate in three groups (P ＞0.05).Conclusion Downregulation with full dose of Gn-RHa without increasing Gn usage turned out a fine outcome in implantation rate and clinical pregnancy rate,a lower abortion rate and less incidence of severe OHSS.It is a safe and effective method of downregulation.关键词
降调节/促性腺激素释放激素激动剂/子宫内膜容受性/体外受精-胚胎移植Key words
Downregulation/Gonadotropin-releasing hormone agonist/The receptivity of endometrium/In vitro fertilization and embryo transplantation
