浙江医学2017，Vol.39Issue(15)：1269-1273,1300,6.DOI:10.12056/j.issn.1006-2785.2017.39.15.2016-1166
克林霉素注射剂不良反应的Meta分析
Adverse effects of clindamycin injection: a meta-analysis
摘要
Abstract
Objective To evaluate the adverse effects of clindamycin injection by meta-analysis.Methods The databases of CNKI,VIP and Wanfang were searched for randomized controlled clinical trials related to clindamycin injection,which were published between 2009 and 2014.Revman5.2 software was used to conduct meta-analysis for the rate of adverse reaction of clindamycin injection.Meanwhile,adverse effects were analyzed by stratification of different indications (adult respiratory system infection,children mycoplasma pneumonia,pelvic inflammatory disease,postpartum endometritis),different ages (＜16 years and ≥16 years),different dosage forms (hydrochloride,phosphate),different doses (≤20 mg/kg ·d,20-60mg/kg·d,＞60 mg/kg,d),different course of treatment(＜7d,=7d,＞7d) and different combinations of drugs (azithromycin,gentamicin,no combined medication).Results Twenty nine studies involving 2581 patients were included in the analysis,patients treated with azithromycin,penicillin and levofloxacin served as the control group.The main adverse reactions were rash,nausea,vomiting,abdominal pain,diarrhea,liver dysfunction,hand and foot twitching.Meta analysis results showed that the overall rate of adverse reaction in clindamycin injection group was 10.85％ and that in control group was 23.04％ (OR=0.40,95％CI:0.32～0.50,P＜0.01).There was no significant difference in adverse effects between clindamycin group and control group in combination with azithromycin (OR=0.73,95％CI:0.43～1.23,P=0.23).The adverse effect rates of clindamycin group were all lower than those of control group in other stratification subgroups.Conclusion Clindamycin injection is used in infectious diseases with low incidence of adverse reactions and good safety.关键词
克林霉素/不良反应/Meta分析/临床随机对照研究Key words
Clindamycin injection/Adverse reaction/Meta analysis/Randomized controlled clinical study引用本文复制引用
潘晨,彭联威,邹慧龙..克林霉素注射剂不良反应的Meta分析[J].浙江医学,2017,39(15):1269-1273,1300,6.基金项目
2013年浙江省药学会医院药学专项科研资助项目(2013ZYY18) （2013ZYY18）
