摘要
Abstract
Objective To assess the efficacy of selective head mild hypothermia combined with murine nerve growth factor in treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on oxidative stress and inflammatory factor expression.Methods One hundred and fifty eight neonates with HIE admitted from January 2014 to June 2016 were randomly assigned to two groups with 79 cases in each group.All patients received routine treatment and selective head hypothermia therapy,patients in study group received additional 30μg murine nerve growth factor i.m,g.d for 2 weeks.The changes of clinical symptoms,neurobehavioral scores (NBNA),psychomotive development index (PDI),mental development index (MDI),oxidative stress index,inflammatory cytokines,neurocognitive factors and adverse reactions were observed and compared between two groups.Results The time for improvement of consciousness,reflex,muscle tension and convulsion in study group was significantly shorter than that in the control group (all P＜0.05).The NBNA,PDI,MDI,SOD and GSH-Px levels were significantly increased and MDA,NO,IL-4,IL-6,hs-CRP,TNF-α and NSE levels were significantly decreased after two weeks of treatment compared to those before treatment in both groups (all P＜0.05).The NBNA,PDI,MDI,SOD and GSH-Px in study group were significantly higher and the MDA,NO,IL-4,IL-6,hs-CRP,TNF-α and NSE levels were significantly lower than those in control group 2 weeks after the treatment (all P＜0.05).The level of NTF in the study group was significantly higher than that before treatment (P＜0.05),but there was no significant difference in NTF level in control group before and after treatment(P ＞0.05).No severe adverse reactions occurred in the two groups during the treatment.Conclusion Selective head mild hypothermia therapy combined with nerve growth factor can significantly improve the clinical symptoms,reduce the level of oxidative stress and neurological inflammatory injury in the treatment of neonate HIE.关键词
亚低温/缺氧缺血性脑病/新生儿/鼠神经生长因子Key words
Mild hypothermia/Hypoxic-ischemic encephalopathy/Neonatal/Rat nerve growth factor
