中医药学报2017，Vol.45Issue(4)：13-15,3.
穿山龙提取物薯蓣皂苷对TNBS诱导的IBS大鼠VIP表达的作用
The Effect of Dioscin from Rhizoma Dioscoreae Nipponicase on VIP Expression in IBS Rats Induced by TNBS
摘要
Abstract
Objective: To investigate tHe vasoactive intestinaL peptides (VIP) expression in irritabLe boweL syndrome (IBS) rats induced by trinitrobenzene suLfonic acid (TNBS), and tHe intervention effects of dioscin from RHizoma Dioscoreae Nipponicase. MetHods: IBS modeLs were estabLisHed by TNBS induction. THe weigHt, myeLoperoxidase (MPO) activity, pain tHresHoLd, and VIP content were detected on tHe days of 2nd, 7tH, 14tH, and 28tH. ResuLts:TNBS induced IBS in rats was confirmed witH weigHt Loss, increased MPO activity, and decreased pain tHresHoLd. VIP pLasma concentration was significantLy increased in rats foLLowing TNBS intervention compared to tHat of tHe controL group(P ＜0. 05), and it was reguLated downwards significantLy. ConcLusion: VIP expression may pLay a roLe in IBS. THerefore,dioscin Has tHerapeutic effect on IBS rats induced by TNBS.关键词
穿山龙/肠易激综合征/血管活性肠肽/三硝基苯磺酸/薯蓣皂苷Key words
Rhizoma Dioscoreae Nipponicase/Irritable bowel syndrome/Vasoactive intestinal peptide/Trinitrobenzene sulfonic acid/Dioscin分类
医药卫生引用本文复制引用
赵旭,张宁,刘国良,周艳丽,代丽娟..穿山龙提取物薯蓣皂苷对TNBS诱导的IBS大鼠VIP表达的作用[J].中医药学报,2017,45(4):13-15,3.基金项目
国家自然科学基金(81274035) （81274035）
黑龙江省中医药科研项目(ZHY16-034) （ZHY16-034）
黑龙江中医药大学科研基金(201516) （201516）
