摘要
Abstract
Objective:To discuss the clinical efficacy of Silibinin for nonalcoholic fatty liver disease(NAFLD) and its influence to their life quality.Methods:88 NAFLD patients were randomly divided into the control group and the observation group, with 44 cases in each group.All patients were given lifestyle interventions, which include diet control, exercise guidance and health education;on this basis, the control group was also intervened with vitamin E, whereas the observation group was intervened with Silibinin.After one courses of treatment (three months), blood lipids, liver function, blood glucose level, clinical efficacy, and life quality were compared between the two groups before and after treatment.Results:The improvements of serum levels of lipids (TG、TC), liver function (ALT、AST) and blood glucose levels (FPG、2hPG、 HbA1c) were significantly in the treatment group more than those in the control group (P<0.05).The effective rate of the observation group was 90.9%, which was significantly higher than 70.5% of the control group (P<0.05).In terms of life quality, the SF-36 score before medication of the observation group was significantly higher than that after medication (P<0.05), of which the improvement degree was significantly better than that of the control group(P<0.05).Conclusion:Silibinin can significantly increase the clinical efficacy for NAFLD patients, it can remarkably improve blood lipid, liver function and blood glucose level, promote the repair of liver injury, and ultimately improve the life quality of the patients.It is an effective adjuvant medication, which is worthy of clinical application.关键词
水飞蓟宾/非酒精性脂肪性肝病/临床疗效/生存质量Key words
Silibinin/Nonalcoholic fatty liver disease(NAFLD)/Clinical efficacy/Life quality分类
医药卫生
